Antibodies against il-13 receptor alpha 1 and uses thereof

Abstract

An antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.

1 - 10 . (canceled) 
     
     
         11 . A recombinant host cell capable that expresses an anti-IL-13Rα1 antibody, comprising variable heavy chain amino acid sequences CDR1, CDR2, and CDR3, and variable light chain amino acid sequences CDR1, CDR2 and CDR3, wherein said variable heavy chain CDR1-3 sequences are selected from the group consisting of the variable heavy chain amino acid sequence CDR1-3 of SEQ ID NO: 1, 3, 5, and 9 and wherein said variable light chain CDR1-3 sequences are selected from the group consisting of the variable light chain amino acid sequence CDR1-3 of SEQ ID NO: 2, 4, 6 and 10; or wherein said variable heavy chain CDR1-3 sequences are selected from the variable heavy chain amino acid sequence CDR1-3 of SEQ ID NO:7 and wherein said variable light chain CDR1-3 sequences are selected from the variable light chain amino acid sequence CDR1-3 of SEQ ID NO:8. 
     
     
         12 . A method for making said anti-IL-13Rα1 antibody of  claim 11 , comprising culturing said recombinant host cell of  claim 11 . 
     
     
         13 . A nucleic acid encoding a polypeptide selected from the group consisting of heavy chain CDRs of SEQ ID NO:1, 3, 5, 7 and 9. 
     
     
         14 . A nucleic acid encoding a polypeptide selected from the group consisting of light chain CDRs of SEQ ID NO:2, 4, 6, 8 and 10 
     
     
         15 . An expression vector comprising a nucleic acid to of  claim 13 , capable of expressing said nucleic acid in a prokaryotic or eukaryotic host cell. 
     
     
         16 . An expression vector comprising a nucleic acid of  claim 14 , capable of expressing said nucleic acid in a prokaryotic or eukaryotic host cell. 
     
     
         17 . An expression vector comprising a nucleic acid of  claim 13  and a nucleic acid of  claim 14 , capable of expressing said nucleic acids in a prokaryotic or eukaryotic host cell. 
     
     
         18 . A prokaryotic or eukaryotic host cell comprising the vector of  claim 17 . 
     
     
         19 . A method for producing a polypeptide capable of binding to IL-13Rα1 and inhibiting the binding of IL-13to IL-13Rα1, comprising:
 expressing a nucleic acid encoding a heavy chain of  claim 13  and a nucleic acid encoding a light chain of  claim 14  in a prokaryotic or eukaryotic host cell; and 
 recovering said polypeptide from said cell. 
 
     
     
         20 . A method for treating a patient in need of an asthma or antiallergic therapy, comprising: administering to the patient a therapeutically effective amount of said antibody of  claim 11 . 
     
     
         21 . (canceled)