System, Method and Apparatus for Purifying Biological Fluids Such as Blood and Constituents Thereof

Abstract

Provided herein is an innovative hemoperfusion system and method including a thermal-fused broad-spectrum biocidal iodinated interactive polymer for the treatment of biological contaminants in body fluids. In one exemplary embodiment, the system and method utilizes a Triosyn® thermal fused broad-spectrum iodinated interactive polymer, included in a hemoperfusion column, for devitalizing high levels of cell-free microorganisms in whole blood and biological fluids in relation with the characterization of blood cells viability and function post-treatment

1 . A method for decontaminating blood, comprising:
 a) providing a hemoperfusion unit containing a low-density chamber including an effective amount of demand disinfectant, said demand disinfectant being an iodinated resin;   b) separating a unit of blood infected with a quantity of bacteria or viral particles to provide a red blood cell concentrate and a plasma concentrate;   c) discarding the plasma concentrate;   d) diluting the red blood cell concentrate with an aqueous solution;   e) filtering said diluted red blood cell concentrate through said hemoperfusion unit at a selected flow rate,   
       wherein the amount of bacteria or viral particles is reduced by greater than 90%.) 
     
     
         2 . The method of  claim 1 , wherein the amount of bacteria or viral particles is reduced by greater than 95%.) 
     
     
         3 . The method of  claim 1 , wherein the amount of bacteria or viral particles is reduced by greater than 99%.) 
     
     
         4 . The method of  claim 1 , wherein the bacteria or viral particles are selected from the group consisting of  Staphylococcus aureus, E. coli  and MS2.) 
     
     
         5 . The method of  claim 1  further comprising gravity filtering red blood cell concentrate through a leukocyte filter to remove leukocytes prior to diluting the red blood cell concentrate.) 
     
     
         6 . The method of  claim 1  further comprising gravity filtering red blood cell concentrate through a leukocyte filter to remove leukocytes after diluting the red blood cell concentrate.) 
     
     
         7 . The method of  claim 1 , wherein the aqueous solution is a saline solution.) 
     
     
         8 . The method of  claim 1 , wherein the said flow rate is 50 ml/mm.) 
     
     
         9 . The method of  claim 1 , wherein the said flow rate is 20 ml/mm.) 
     
     
         10 . The method of  claim 1 , wherein the a low-density chamber further contains hydrodynamic diffusers.