Cancer treatment using viruses, fluoropyrimidines and camptothecins

Abstract

Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.

1 . A method of treating a mammalian subject having a neoplasm, comprising administering to the subject a virus, a fluoropyrimidine, and a camptothecin compound in one or more cycles in a combined amount effective to treat the subject;
 wherein the virus is selected from the group consisting of a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus.   
     
     
         3 . The method of  claim 1 , wherein the virus is administered intravenously. 
     
     
         4 . The method of  claim 1  wherein the fluoropyrimidine compound is 5-fluorouracil. 
     
     
         5 . The method of  claim 4 , further comprising administering to the subject leucovorin. 
     
     
         6 . The method of  claim 4 , wherein the 5-fluorouracil is administered by continuous infusion over a period of at least 22 hours per dose. 
     
     
         7 . The method of  claim 1  wherein the camptothecin compound is selected from the group consisting of topotecan, 9-aminocamptothecin, exatecan, karenitecin, rubitecan, lurtotecan, and a homocamptothecin. 
     
     
         8 . The method of  claim 1 , wherein the camptothecin compound is irinotecan. 
     
     
         9 . The method of  claim 1 , wherein the fluoropyrimidine compound is 5-fluorouracil, and the camptothecin compound is irinotecan. 
     
     
         10 . The method of  claim 1 , wherein the virus, the fluoropyrimidine compound, and the camptothecin compound are administered in two or more cycles. 
     
     
         11 . The method of  claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month before administration of the virus. 
     
     
         12 . The method of  claim 11 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week before administration of the virus. 
     
     
         13 . The method of  claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month after administration of the virus. 
     
     
         14 . The method of  claim 13 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week after administration of the virus. 
     
     
         15 . The method of  claim 1 , wherein the neoplasm is a colon carcinoma.