Carbamoyl derivatives of bicyclic carbonylamino-pyrazoles as prodrugs

Abstract

There are provided bicyclic carbonylamino-pyrazoles of formula (I), wherein the variables are as specified in the claims, for use as medicament, in particular for the treatment of diseases due to the malfunctioning of protein kinases (PKs), such as cancer, pharmaceutical compositions comprising such carbamoyl derivatives, and their use as prodrugs of therapeutically active agents. Method of treatment and some new bicyclic carbonylamino-pyrazoles are also object of the present invention.

1 . A compound of the formula (I): 
       
         
           
           
               
               
           
         
       
       wherein
 R represents a straight or branched C 1 -C 12  alkyl, an aryl or heteroaryl group, 
 R 1  represents a hydrogen atom or a substituent attached to any available atom of the A ring, 
 R 2  represents an optionally substituted group selected from straight or branched C 1 -C 6  alkyl, aryl, heteroaryl, C 3 -C 6  cycloalkyl, C 2 -C 6  alkenyl or alkynyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, aryl C 1 -C 6  alkyl, heteroaryl C 1 -C 6  alkyl, a 5 or 6 membered heterocyclyl and heterocyclyl C 1 -C 6  alkyl with from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulphur, 
 A ring represents a phenyl or a heterocycle and 
 m is a value from 1 to 6, 
 
       or a pharmaceutically acceptable salt thereof, for use as a medicament. 
     
     
         2 . A compound of formula (I) as defined in  claim 1  for use as a prodrug. 
     
     
         3 . A compound of formula (I) according to  claim 2 , characterized it is for use as prodrug for treating cell proliferative disorders caused by and/or associated with an altered protein kinase activity. 
     
     
         4 . A compound of formula (I) according to  claim 3 , characterized it is for use as prodrug for treating cancer. 
     
     
         5 . A compound of the formula (I) as defined in claim characterized in that R does not represent an usubstituted ethyl group. 
     
     
         6 . A pharmaceutical composition comprising a compound of formula (I) as defined in  claim 1  or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable excipient. 
     
     
         7 . A therapeutic method of treatment using as prodrug a compound of the formula (I) as defined in  claim 1 . 
     
     
         8 . A method for treating cell proliferative disorders caused by and/or associated with an altered protein kinase activity, which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I) as defined in  claim 1  or a pharmaceutical composition as specified herein. 
     
     
         9 . A method according to  claim 8 , characterized in that the cell proliferative disorder is cancer. 
     
     
         10 . A compound of the formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof for use as a medicament. 
     
     
         11 . A compound as defined in  claim 10  for use as a prodrug. 
     
     
         12 . A compound according to  claim 11 , characterized it is for use as prodrug for treating cell proliferative disorders caused by and/or associated with an altered protein kinase activity. 
     
     
         13 . A compound according to  claim 12 , characterized it is for use as prodrug for treating cancer. 
     
     
         14 . A compound selected from the group consisting of:
 A01 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid methyl ester;   A02 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester;   A03 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid vinyl ester;   A04 5-(2,6-Diethyl-phenyl carbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid propyl ester;   A05 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid isopropyl ester;   A06 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid allyl ester;   A07 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid propargyl ester;   A08 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid butyl ester;   A09 5-(2,6-Diethyl-phenyl carbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid isobutyl ester;   A010 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid sec-butyl ester;   A011 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid tert-butyl ester;   A012 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid pentyl ester;   A013 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid neopentyl ester;   A014 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid hexyl ester;   A015 5-(2,6-Diethyl-phenyl carbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid heptyl ester;   A016 5-(2,6-Diethyl-phenyl carbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid benzyl ester;   A017 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid phenyl ester;   A018 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   A019 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid cyclopentyl ester;   A020 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   A021 5-(2,6-Diethyl-phenyl carbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   A022 5-(2,6-Diethyl-phenylcarbamoyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   A023 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid methyl ester;   A024 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester;   A025 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid vinyl ester;   A026 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid propyl ester;   A027 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid isopropyl ester;   A028 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid allyl ester;   A029 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid propargyl ester;   A030 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid butyl ester;   A031 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid sec-butyl ester;   A032 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid isobutyl ester;   A033 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid tert-butyl ester;   A034 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid pentyl ester;   A035 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid neopentyl ester;   A036 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid hexyl ester;   A037 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid heptyl ester;   A038 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid benzyl ester;   A039 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid phenyl ester;   A040 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid cyclopentyl ester;   A041 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   A042 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   A043 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   A044 5-((R)-2-Methoxy-2-phenyl-acetyl)-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   B01 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid methyl ester;   B02 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid ethyl ester;   B03 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid vinyl ester;   B04 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid propyl ester;   B05 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid isopropyl ester;   B06 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid allyl ester;   B07 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid propargyl ester;   B08 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid butyl ester;   B09 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid isobutyl ester;   B010 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid sec-butyl ester;   B011 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid tert-butyl ester;   B012 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid pentyl ester;   B013 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid neopentyl ester;   B014 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid hexyl ester;   B015 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid heptyl ester;   B016 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid benzyl ester;   B017 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid phenyl ester;   B018 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid cyclopentyl ester;   B019 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   B020 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   B021 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   B022 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-furo[3,2-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   B023 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid methyl ester;   B024 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid ethyl ester;   B025 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid vinyl ester;   B026 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid propyl ester;   B027 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid isopropyl ester;   B028 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid allyl ester;   B029 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid propargyl ester;   B030 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid butyl ester;   B031 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid isobutyl ester;   B032 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid sec-butyl ester;   B033 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid tert-butyl ester;   B034 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid pentyl ester;   B035 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid neopentyl ester;   B036 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid hexyl ester;   B037 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid heptyl ester;   B038 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid benzyl ester;   B039 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid phenyl ester;   B040 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid cyclopentyl ester;   B041 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   B042 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   B043 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   B044 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-pyrrolidin-1-ylmethyl-benzoylamino)-furo[3,2-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   B045 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid methyl ester;   B046 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid ethyl ester;   B047 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid vinyl ester;   B048 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid propyl ester;   B049 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid isopropyl ester;   B050 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid allyl ester;   B051 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid propargyl ester;   B052 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid butyl ester;   B053 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid isobutyl ester;   B054 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid sec-butyl ester;   B055 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid tert-butyl ester;   B056 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid pentyl ester;   B057 5-(1-Methyl-1-phenyl-ethyl carbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid neopentyl ester;   B058 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid hexyl ester;   B059 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid heptyl ester;   B060 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid benzyl ester;   B061 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid phenyl ester;   B062 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid cyclopentyl ester;   B063 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   B064 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   B065 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   B066 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(2-methyl-2H-pyrazole-3-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   B067 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid methyl ester;   B068 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid ethyl ester;   B069 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid vinyl ester;   B070 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid propyl ester;   B071 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid isopropyl ester;   B072 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid allyl ester;   B073 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid propargyl ester;   B074 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid butyl ester;   B075 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid isobutyl ester;   B076 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid sec-butyl ester;   B077 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid tert-butyl ester;   B078 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid pentyl ester;   B079 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid neopentyl ester;   B080 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid hexyl ester;   B081 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid heptyl ester;   B082 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid benzyl ester;   B083 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid phenyl ester;   B084 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   B085 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid cyclopentyl ester;   B086 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   B087 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   B088 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoylamino}-furo[3,2-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C01 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C02 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C03 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C04 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C05 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C06 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C07 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C08 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C09 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C010 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C011 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C012 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C013 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C014 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C015 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C016 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C017 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C018 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C019 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C020 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C021 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroyethyl ester;   C022 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C023 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C024 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C025 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C026 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C027 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C028 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C029 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C030 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C031 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C032 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C033 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C034 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C035 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C036 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C037 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C038 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C039 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C040 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C041 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C042 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C043 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C044 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-(4-morpholin-4-yl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C045 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C046 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C047 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C048 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C049 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C050 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C051 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C052 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C053 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C054 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C055 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C056 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C057 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C058 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C059 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C060 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C061 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C062 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C063 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C064 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C065 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C066 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C067 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C068 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C069 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C070 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C071 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C072 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C073 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C074 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C075 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C076 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C077 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C078 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C079 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C080 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C081 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C082 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C083 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C084 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C085 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C086 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C087 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C088 3-[4-(Isopropylamino-methyl)-benzoylamino]-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C089 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C090 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C091 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C092 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C093 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C094 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C095 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C096 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C097 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C098 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C099 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C0100 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C0101 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C0102 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C0103 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C0104 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C0105 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C0106 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C0107 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C0108 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C0109 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C0110 5-[1-(2-Chloro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-piperidin-1-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C0111 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C0112 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C0113 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C0114 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C0115 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C0116 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C0117 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C0118 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C0119 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C0120 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C0121 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C0122 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C0123 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C0124 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C0125 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C0126 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C0127 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C0128 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C0129 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C0130 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C0131 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C0132 5-[1-(2-Fluoro-phenyl)-1-methyl-ethylcarbamoyl]-3-(4-morpholin-4-ylmethyl-benzoylamino)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C0133 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C0134 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C0135 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C0136 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C0137 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C0138 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C0139 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C0140 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C0141 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C0142 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C0143 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C0144 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C0145 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C0146 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C0147 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C0148 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C0149 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid phenyl ester;   C0150 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C0151 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C0152 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C0153 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C0154 3-{2-[(1-Methyl-1H-imidazole-2-carbonyl)-amino]-benzoylamino}-5-(1-methyl-1-phenyl-ethylcarbamoyl)-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C0155 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid methyl ester;   C0156 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid ethyl ester;   C0157 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid vinyl ester;   C0158 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl carbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid propyl ester;   C0159 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid isopropyl ester;   C0160 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid allyl ester;   C0161 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid propargyl ester;   C0162 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid butyl ester;   C0163 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid isobutyl ester;   C0164 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid sec-butyl ester;   C0165 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl carbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid tert-butyl ester;   C0166 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid pentyl ester;   C0167 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid neopentyl ester;   C0168 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid hexyl ester;   C0169 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid heptyl ester;   C0170 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid benzyl ester;   C0171 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid phenyl ester;   C0172 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C0173 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C0174 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C0175 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C0176 3-(4-Morpholin-4-yl-benzoylamino)-5-((S)-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-thieno[3,2-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   C0177 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid methyl ester;   C0178 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester;   C0179 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid vinyl ester;   C0180 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid propyl ester;   C0181 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid isopropyl ester;   C0182 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid allyl ester;   C0183 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid propargyl ester;   C0184 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid butyl ester;   C0185 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid isobutyl ester;   C0186 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid sec-butyl ester;   C0187 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid tert-butyl ester;   C0188 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid pentyl ester;   C0189 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid neopentyl ester;   C0190 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid hexyl ester;   C0191 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C0192 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid heptyl ester;   C0193 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid benzyl ester;   C0194 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid cyclopentyl ester;   C0195 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid 2-methoxyethyl ester;   C0196 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester;   C0197 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid 2-fluoroethyl ester;   C0198 5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-3-carbonyl)-amino]-benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid 2-chloroethyl ester;   D01 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D02 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D03 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D04 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D05 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D06 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D07 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D08 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D09 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D010 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D011 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D012 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D013 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D014 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D015 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D016 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D017 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D018 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D019 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ispropyl ester;   D020 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D021 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D022 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D023 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D024 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D025 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D026 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D027 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid isopropyl ester;   D028 5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D029 5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D030 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D031 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D032 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D033 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D034 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D035 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D036 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D037 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D038 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D039 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D040 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D041 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D042 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D043 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D044 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D045 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D046 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ispropyl ester;   D047 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D048 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D049 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D050 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D051 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D052 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D053 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D054 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid isopropyl ester;   D055 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D056 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D057 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D058 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D059 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D060 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D061 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D062 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D063 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D064 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D065 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D066 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D067 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D068 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D069 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D070 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D071 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D072 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D073 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ispropyl ester;   D074 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D075 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D076 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D077 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D078 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D079 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D080 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D081 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid isopropyl ester;   D082 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D083 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D084 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D085 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D086 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D087 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D088 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D089 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D090 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D091 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-ethyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D092 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D093 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D094 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D095 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D096 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-[(2-dimethylamino-propyl)-methyl-amino]-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   D097 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D098 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D099 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D0100 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ispropyl ester;   D0101 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D0102 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D0103 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-methoxy-ethyl ester;   D0104 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-pyrrolidin-1-yl-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid 2-ethoxy-ethyl ester;   D0105 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid methyl ester;   D0106 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid ethyl ester;   D0107 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid propyl ester;   D0108 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-1-carboxylic acid isopropyl ester;   E01 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E02 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E03 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E04 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   E05 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E06 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E07 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E08 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E09 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E010 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E011 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E012 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E013 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E014 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E015 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E016 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E017 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E018 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E019 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E020 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(tetrahydro-pyran-4-ylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E021 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E022 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E023 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   E024 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E025 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E026 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E027 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E028 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E029 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E030 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E031 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E032 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E033 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E034 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E035 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E036 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E037 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E038 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E039 5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E040 5-(3,5-Difluoro-benzenesulfonyl)-3-[2-((S)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E041 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E042 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E043 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   E044 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E045 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E046 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E047 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E048 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E049 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E050 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E051 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E052 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E053 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E054 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E055 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E056 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E057 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E058 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E059 S-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E060 5-(3,5-Difluoro-benzenesulfonyl)-3-[2-((R)-2-methoxy-1-methyl-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E061 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E062 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E063 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(4-methyl-piperazin-1-yl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-(2-methoxy-ethoxy)-ethyl ester;   E064 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E065 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E066 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E067 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E068 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E069 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E070 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E071 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-propyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E072 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E073 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E074 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E075 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(2-dimethylamino-ethoxy)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester;   E076 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid methyl ester;   E077 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid ethyl ester;   E078 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-methoxy-ethyl ester;   E079 R-5-(3,5-Difluoro-benzenesulfonyl)-3-[4-(pyrrolidin-1-ylmethyl)-2-(2-methoxy-1-methyl-ethylamino)-benzoylamino]-indazole-1-carboxylic acid 2-ethoxy-ethyl ester and   E080 5-(3,5-Difluoro-benzenesulfonyl)-3-[2-(2-methoxy-ethylamino)-4-(4-methyl-piperazin-1-yl)-benzoylamino]-indazole-1-carboxylic acid ethyl ester, for use as medicament.   
     
     
         15 . A compound of  claim 14 , with the exclusion of compounds coded A02, A024 and C024, or a pharmaceutically acceptable salt thereof.