Method Of Delivering Stable Topical Drug Compositions

Abstract

A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature.

1 . A method for administering a polypeptide drug comprising:
 applying a composition containing:
 an effective amount of a polypeptide drug, and 
 a phosphatidylcholine and polyglycol multilamellar liquid crystal non-liposome carrier entrapping and stabilizing the polypeptide drug at room temperature; 
   to human skin whereby the carrier penetration the skin and delivers the polypeptide drug to the dermal vasculature.   
     
     
         2 . The method of  claim 1 , wherein said polyglycol comprises polyglycol having a molecular weight and polyglycol having a molecular weight of 400. 
     
     
         3 . The method of  claim 2  wherein weight percentages of said phosphatidylcholine and polyglycol are 45% w/w polyenylphosphatidylcholine, 50% w/w polyglycol having a molecular weight of 200, and 5% w/w polyglycol having a molecular weight of 400. 
     
     
         4 . The method of  claim 1 , wherein said carrier comprises a surfactant, a lubricant, and methyl paraben. 
     
     
         5 . The method of  claim 4  wherein said carrier comprises 97.25% w/w phosphatidylcholine and polyglycol, 1.00% w/w surfactant, 1.00% w/w lubricant, and 0.75% methyl paraben. 
     
     
         6 . The method of  claim 4 , wherein said carrier further comprises water. 
     
     
         7 . The method of  claim 6 , wherein said carrier comprises 53.25% w/w phosphatidylcholine and polyglycol, 1.00% w/w surfactant, 1.00% w/w lubricant, 0.75% w/w methyl paraben and 44% w/w water. 
     
     
         8 . The method of  claim 7 , wherein said surfactant is a siloxylated polyether. 
     
     
         9 . The method of  claim 8 , wherein said siloxylated polyether is dimethyl, methyl(propylpolyethylene oxide propylene oxide, acetate) siloxane. 
     
     
         10 . The method of  claim 4 , wherein said lubricant is silicone fluid. 
     
     
         11 . The method of  claim 10 , wherein said silicone fluid contains low viscosity polydimethylsiloxane polymers. 
     
     
         12 . The method of  claim 1 , wherein said drug is selected from the group consisting of oxytocin, vasopressin, insulin, somatotropin, calcitonin, chorionic gonadotropin, menotropins, follitropins, somatostatins, progestins, and combinations of any of these. 
     
     
         13 . A method for administering a drug comprising:
 applying a composition containing:
 an effective amount of a drug, and 
 a phosphatidylcholine and polyglycol multilamellar liquid crystal non-liposome carrier entrapping and stabilizing the drug at room temperature; 
   to human skin whereby the carrier penetration the skin and delivers the drug to dermal vasculature in the human skin.   
     
     
         14 . A method for administering a drug comprising:
 applying a composition containing:
 an effective amount of a drug, and 
 a phosphatidylcholine based multilamellar liquid crystal non-liposome carrier entrapping and stabilizing the drug at room temperature; 
   to human skin whereby the carrier penetration the skin and delivers the drug to dermal vasculature in the human skin.   
     
     
         15 . The method of  claim 14 , wherein said hosphatidylcholine based multilamellar liquid crystal non-liposome carrier further comprises polyglycol. 
     
     
         16 . The method of  claim 15 , wherein said polyglycol comprises polyglycol having a molecular weight and polyglycol having a molecular weight of 400. 
     
     
         17 . The method of  claim 15  wherein weight percentages of said phosphatidylcholine and polyglycol are 45% w/w polyenylphosphatidylcholine, 50% w/w polyglycol having a molecular weight of 200, and 5% w/w polyglycol having a molecular weight of 400. 
     
     
         18 . The method of  claim 15 , wherein said carrier comprises a surfactant, a lubricant, and methyl paraben. 
     
     
         19 . The method of  claim 15 , wherein said drug is selected from the group consisting of oxytocin, vasopressin, insulin, somatotropin, calcitonin, chorionic gonadotropin, menotropins, follitropins, somatostatins, progestins, and combinations of any of these.