Calcium Carbonate Granulation

Abstract

Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.

1 . A granulated composition comprising:
 i. a first powdered composition comprising a median particle diameter from about 10 to about 25 μm; and   ii. a second powdered composition comprising a median particle diameter from about 0.1 to about 10 μm.   
     
     
         2 . The granulated composition of  claim 1  wherein at least one of said first and second powdered compositions comprise calcium carbonate. 
     
     
         3 . The granulated composition of  claim 1  wherein said first and second powdered compositions each comprise calcium carbonate. 
     
     
         4 . The granulated composition of any of  claims 1 - 3  wherein said first powdered composition comprises from about 50 to about 100 weight % of the granulated composition and said second powdered composition comprises from about 0 to about 50 weight % of the granulated composition. 
     
     
         5 . The granulated composition of any of  claims 1 - 3  wherein said first powdered composition has a median particle diameter from about 12 to about 17 μm and said second powdered composition has a median particle diameter from about 1 to about 5 μm. 
     
     
         6 . The granulated composition of any of  claims 1 - 3  wherein said first powdered composition has a median particle diameter of about 15 μm and said second powdered composition has a median particle diameter of about 4 μm. 
     
     
         7 . A granulated composition comprising:
 i. a first powdered composition having a median particle diameter from about 10 to about 25 μm;   ii. a second powdered composition having a median particle diameter from about 1 to about 10 μm; and   iii. a third powdered composition having a median particle diameter from about 0.1 to about 1 μm.   
     
     
         8 . The granulated composition of  claim 7  wherein at least one of said first, second, and third powdered compositions comprises calcium carbonate. 
     
     
         9 . The granulated composition of  claim 7  wherein each of said first, second, and third powdered compositions comprises calcium carbonate. 
     
     
         10 . The granulated composition of any of  claims 7 - 9  wherein said first powdered composition comprises from about 50 to about 100 weight % of the granulated composition, said second powdered composition comprises from about 10 to about 50 weight % of the granulated composition, and said third powdered composition comprises from about 0 to about 20 weight % of the granulated composition. 
     
     
         11 . The granulated composition of any of  claims 7 - 9  wherein said first powdered composition has a median particle diameter from about 12 to about 17 μm; said second powdered composition has a median particle diameter from about 1 to about 5 μm; and said third powdered composition has a median particle diameter from about 0.5 to about 1 μm. 
     
     
         12 . The granulated composition of any of  claims 7 - 9  wherein said first powdered composition has a median particle diameter of about 15 μm; said second powdered composition has a median particle diameter of about 10 μm; and said third powdered composition has a median particle diameter of about 0.7 μm. 
     
     
         13 . A tablet comprising the granulated composition of  claim 1  or  7 .