Novel mycobacterial inhibitors

Abstract

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases. In particular, compounds are claimed in which, independently from each other, R 1 is halo; p=1; R 2 is optionally substituted alkyloxy, alkyl, Ar, Het, or a radical of formula R 3 is optionally substituted Ar or Het; q=1, R 4 and R 5 each independently are alkyl; R 6 is hydrogen or a radical of formula r is equal to 0 or 1 and R 7 is hydrogen or Ar. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.

1 - 16 . (canceled) 
     
     
         17 . A compound having the formula; 
       
         
           
           
               
               
           
         
       
       the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. 
     
     
         18 . A compound having the formula; 
       
         
           
           
               
               
           
         
       
       the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. 
     
     
         19 . A compound having the formula; 
       
         
           
           
               
               
           
         
       
       the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. 
     
     
         20 . A compound having the formula; 
       
         
           
           
               
               
           
         
       
       the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof.