Methods For Selectively Modulating Survivin Apoptosis Pathways

Abstract

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34 cdc2 -cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.

1 - 29 . (canceled) 
     
     
         30 . A method of inhibiting the growth of a tumor cell comprising administering an effective amount of an antisense survivin nucleic acid to the tumor cell. 
     
     
         31 . The method of  claim 30 , wherein the tumor cell is in a tumor mass. 
     
     
         32 . The method of  claim 31 , wherein the tumor mass is present in a mammal. 
     
     
         33 . The method of  claim 32 , wherein the tumor mass is a melanoma. 
     
     
         34 . The method of  claim 31 , wherein the method inhibits the growth of a tumor mass in vivo. 
     
     
         35 . The method of  claim 30 , wherein the method inhibits the growth of a tumor cell in vitro. 
     
     
         36 . The method of  claim 30 , wherein the method inhibits the growth of a tumor cell is in vivo.