Methods of using sustained release aminopyridine compositions

Abstract

A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.

1 . A method of establishing steady state plasma pharmacokinetics of 4-aminopyridine, said method comprising administering sustained release 4-aminopyridine, as set forth herein. 
     
     
         2 . The method of  claim 1  further comprising a step of maintaining the steady state plasma pharmacokinetics of 4-aminopyridine.