Apheresis device

Abstract

The invention relates to an apharesis device for use in the treatment of Alzheimer patients. Said device comprises a solid support with which a flow of blood or plasma can be contacted.

1 . An apheresis device comprising a solid carrier capable of being contacted with the blood or plasma flow, wherein the solid carrier includes an amyloid-β-precursor-protein (APP)-binding receptor. 
     
     
         2 . A device according to  claim 1 , wherein the APP-binding receptor is selected from an anti-APP antibody, an anti-Aβ 40  antibody, an anti-Aβ 42  antibody, an APP-binding protein, an APP-binding peptide, an APP-binding gangloside, an APP-binding nucleic acid acids, or a combination thereof. 
     
     
         3 . A device according to  claim 1 , wherein the carrier is a sterile and pyrogen-free column. 
     
     
         4 . (canceled) 
     
     
         5 . A device according to  claim 2 , wherein the carrier is a sterile and pyrogen-free column. 
     
     
         6 . A device according to  claim 1 , wherein the APP-binding receptor is an APP-binding protein selected from the group consisting of gelsolin, apoJ and apoE. 
     
     
         7 . A device according to  claim 1 , wherein the anti-APP-antibody is an anti-Abeta 40 antibody. 
     
     
         8 . A device according to  claim 1 , wherein the anti-APP-antibody is an anti-Abeta 42 antibody.