Method of maintaining oral health in animals

Abstract

Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholiπo ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.

1 . A method for preventing or treating a disease caused by oral bacteria in a non-human animal, wherein said method comprises administering to the animal a compound of formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . The method, according to  claim 1 , wherein the sum of the carbon atoms in the groups R 1  and R 2  of the morpholino compound is at least 10. 
     
     
         3 . The method, according to  claim 1 , wherein R 2  of the morpholino compound terminates with the hydroxy group. 
     
     
         4 . The method, according to  claim 1 , wherein the morpholino compound is 3-(4-propyl-heptyl)-4-(2-hydroxyethyl)morpholine. 
     
     
         5 . The method, according to  claim 1 , wherein the animal is a companion animal. 
     
     
         6 . The method, according to  claim 5 , wherein the animal is a dog. 
     
     
         7 . The method, according to  claim 5 , wherein the animal is a cat. 
     
     
         8 . The method, according to  claim 1 , which further comprises administering an antimicrobial agent. 
     
     
         9 . The method, according to  claim 1 , wherein the compound is administered in a formulation that further comprises a pharmaceutically acceptable excipient. 
     
     
         10 . The method, according to  claim 1 , wherein the compound is administered in a formulation that further comprises an anti-inflammatory agent. 
     
     
         11 . The method, according to  claim 1 , wherein the compound is administered in an aqueous formulation. 
     
     
         12 . The method, according to  claim 1 , wherein the compound is administered in a formulation that is in the form of a toothpaste, gum or mouthwash. 
     
     
         13 . The method, according to  claim 1 , wherein the compound of formula (I) prevents or removes plaque formation in the oral cavity. 
     
     
         14 . The method, according to  claim 1 , wherein the compound of formula (I) prevents or treats gum disease. 
     
     
         15 . The method, according to  claim 14 , wherein the gum disease is gingivitis or periodontitis. 
     
     
         16 . The method, according to  claim 1 , wherein the disease is halitosis. 
     
     
         17 . The method, according to  claim 16 , which reduces the level of Volatile Sulphur Compounds emitted from the oral cavity. 
     
     
         18 . A cosmetic method of preventing or decreasing oral staining in an animal, comprising the step of exposing the oral cavity to a morpholino compound of general formula (I); 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         19 . The cosmetic method according to  claim 18 , wherein the teeth are whitened. 
     
     
         20 . The method according to  claim 18 , wherein the staining is from dietary stains. 
     
     
         21 . The method according to  claim 18 , additionally comprising brushing the oral cavity. 
     
     
         22 . The method according to  claim 18 , wherein the animal is a companion animal. 
     
     
         23 . The method according to  claim 22 , wherein the companion animal is a dog. 
     
     
         24 . The method according to  claim 22 , wherein the companion animal is a cat. 
     
     
         25 . An animal chew comprising a compound of formula (I); 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         26 . The animal chew according to  claim 25 , wherein the compound is infused into the chew. 
     
     
         27 . The animal chew according to  claim 25 , wherein the chew comprises animal hide. 
     
     
         28 . The animal chew according to  claim 25 , wherein the chew comprises a man-made material. 
     
     
         29 . The animal chew according to  claim 25 , comprising at least one flavouring. 
     
     
         30 . The animal chew according to  claim 25  designed for use by dogs. 
     
     
         31 . An animal foodstuff comprising a compound according to formula (I); 
       
         
           
           
               
               
           
         
         wherein R 1  is a straight or branched alkyl croup containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R 2  is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. 
       
     
     
         32 . The animal foodstuff according to  claim 31 , wherein the foodstuff is a biscuit.