US2011177121A1PendingUtilityA1

Immunogenic Influenza Composition

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Assignee: BIOLOG MIMETICS INCPriority: Feb 21, 2008Filed: Feb 20, 2009Published: Jul 21, 2011
Est. expiryFeb 21, 2028(~1.6 yrs left)· nominal 20-yr term from priority
Inventors:Peter L. NaraGregory J. TobinGeorge Lin
A61K 39/12A61K 2039/53A61K 39/145A61K 2039/525A61K 2039/5258A61K 2039/55566C12N 2760/16134A61P 37/04A61K 2039/5252A61P 31/16
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Claims

Abstract

Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Claims

exact text as granted — not AI-modified
1 . An isolated composition comprising an immunogenic epitope of influenza that is not immunodominant as in a wild type virus. 
     
     
         2 . The composition of  claim 1  comprising a hemagglutinin. 
     
     
         3 . The composition of  claim 1  comprising a neuraminidase. 
     
     
         4 . The composition of  claim 1  comprising an influenza virus particle. 
     
     
         5 . The composition of  claim 4 , wherein said particle is inactivated. 
     
     
         6 . The composition of  claim 1  wherein said composition comprises addition or removal of a glycosylation site. 
     
     
         7 . The composition of  claim 1 , wherein said composition comprises an amino acid addition, substitution or deletion. 
     
     
         8 . The composition of  claim 1  comprising a virus-like particle. 
     
     
         9 . The composition of  claim 1  expressed on the surface of influenza virus. 
     
     
         10 . The composition of  claim 1 , further comprising a pharmaceutically acceptable carrier, diluent or excipient.

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