Peptides capable of modulating the function of tirc7

Abstract

Provided are peptides capable of inhibiting proliferation of peripheral blood mononuclear cells (PBMCs) derived from the third extracellular domain of T-cell immune response cDNA7 (TIRC7) costimulatory molecule are described. Compositions comprising such peptides and their use for the treatment of immune diseases are provided.

1 . A peptide capable of inhibiting proliferation of peripheral blood mononuclear cells, comprising a fragment of the amino acid sequence from the third extracellular domain of T cell immune response cDNA 7 protein. 
     
     
         2 . The peptide of  claim 1 , which comprises a fragment of the amino acid sequence shown in SEQ ID NO: 1. 
     
     
         3 . The peptide of  claim 1  comprising or consisting of an amino acid sequence as shown in any one of SEQ ID NOs: 1 to 5, or a fragment thereof. 
     
     
         4 . The peptide of  claim 1 , wherein said peptide comprises at least one selected from the group consisting of D-isomer amino acids, L-isomer amino acids, and a combination thereof. 
     
     
         5 . The peptide of  claim 1 , further comprising a heterologous amino acid or amino acid sequence at least one of its N- and C-terminus. 
     
     
         6 . The peptide of  claim 1 , wherein said heterologous amino acid sequence comprises a His-tag or DHFR. 
     
     
         7 . The peptide of  claim 1 , wherein said peptide comprises the amino acid sequence of SEQ ID NO: 6 or 7. 
     
     
         8 . A composition comprising at least one peptide of  claim 1 . 
     
     
         9 . The composition of  claim 8  which is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier. 
     
     
         10 . The pharmaceutical composition of  claim 9  further comprising an immunosuppressive.