Biological Matrix for Cardiac Repair

Abstract

Provided herein is a device to occlude a hole in a wall of an organ or tissue. In another embodiment, a device is provided which comprises an extracellular matrix-derived material and an adhesive to occlude a hole in a wall of an organ or tissue. Provided are devices prepared from extracellular matrix-derived cell-growth scaffolding to repair defects in walls of organs or tissues. Also provided are methods for preparing the device as well as for using the device.

1 . An occluding device, comprising an occluding member attached to a collapsible frame and the collapsible frame further comprising a distal sealing portion, a proximal sealing portion, a connector between the sealing portions and a fastener attached to the proximal sealing portion and/or the connector, wherein the fastener allows for manipulation and retrieval of the device. 
     
     
         2 . The device of  claim 1 , wherein the fastener is a threaded bore or a bolt from a bolt-and-nut type clasp. 
     
     
         3 . The device of  claim 1 , wherein the collapsible frame is an elastic material. 
     
     
         4 . The device of  claim 3 , wherein the elastic material comprises a metal. 
     
     
         5 . The device of  claim 4 , wherein the metal is an elastic wire. 
     
     
         6 . The device of  claim 5 , wherein the elastic wire is a nickel-titanium alloy. 
     
     
         7 . The device of  claim 1 , wherein the distal and proximal sealing portion are a polymer. 
     
     
         8 . The device of  claim 1 , wherein the distal and proximal sealing portion are ECM-derived material. 
     
     
         9 . The device of  claim 8  wherein the elastic material is cross-linked extracellular matrix tissue. 
     
     
         10 . The device of  claim 1 , wherein the proximal and distal sealing portions are cambered. 
     
     
         11 . The device of  claim 1 , wherein the proximal and distal sealing portions comprise eyelets. 
     
     
         12 . The device of  claim 11 , wherein a grafting material is attached to the eyelets on the proximal portion of the frame. 
     
     
         13 . The device of  claim 12 , wherein the eyelets are configured to allow for manipulation and retrieval of the device. 
     
     
         14 . The device of  claim 13 , wherein the eyelets comprise sutures. 
     
     
         15 . The device of  claim 1 , wherein the connector between the proximal and distal portions of the frame comprises one or more shape memory fibers. 
     
     
         16 . The device of  claim 1 , wherein the connector consists of a single spring-shaped memory fiber. 
     
     
         17 . The device of  claim 16 , were the connector comprises a plurality of shape memory fibers extending from the proximal to the distal portion and formed into a preset shape of a twisted bundle, and which can be untwisted by rotating one or both of the proximal and distal portions relative to each other. 
     
     
         18 . The device of  claim 17 , wherein the shape memory fibers comprise a material selected from the group consisting of nitinol, polylactide, and magnesium alloy. 
     
     
         19 . The device of  claim 18 , wherein magnesium alloy is an absorbable metal. 
     
     
         20 . The device of  claim 1 , wherein the device comprises a grafting material. 
     
     
         21 . The device of  claim 20 , wherein the grafting material comprises extracellular matrix (ECM) tissue isolated from urinary bladder tissue. 
     
     
         22 . The device of  claim 21 , wherein the extracellular matrix (ECM) tissue isolated from urinary bladder tissue and having an abluminal side is fixed such that the abluminal side is facing away from the device. 
     
     
         23 . A method of treating a patient having a heart defect, comprising implanting the device of  claim 1  in the heart of the patient. 
     
     
         24 . The method of  claim 23 , wherein the heart defect of the patient is an atrial septal defect (ASD).