Methods and materials for producing immune responses against polypeptides involved in antibiotic resistance

Abstract

This document relates to methods and materials for producing immune responses against polypeptides involved in antibiotic resistance. For example, vaccines against polypeptides involved in antibiotic resistance as well as methods for vaccinating mammals against polypeptides involved in antibiotic resistance are provided.

1 . A method for inducing an immune response against a polypeptide involved in antibiotic resistance, said method comprising administering to an animal an amount of said polypeptide or a nucleic acid encoding said polypeptide effective for producing said immune response. 
     
     
         2 . The method of  claim 1 , wherein said polypeptide is a blaZ polypeptide, a mecA polypeptide, a whiB7 polypeptide, a tap polypeptide, a RV1473 polypeptide, a katG polypeptide, an inhA polypeptide, a rpoB polypeptide, a gidB polypeptide, a pncA polypeptide, an embB polypeptide, or a gyrA polypeptide. 
     
     
         3 . The method of  claim 1 , wherein said polypeptide is a blaZ polypeptide. 
     
     
         4 . The method of  claim 1 , wherein said polypeptide is a mecA polypeptide. 
     
     
         5 . The method of  claim 1 , wherein said antibiotic resistance is penicillin-resistance. 
     
     
         6 . The method of  claim 1 , wherein said antibiotic resistance is methicillin-resistance. 
     
     
         7 . The method of  claim 1 , wherein said antibiotic resistance is vancomycin-resistance. 
     
     
         8 . The method of  claim 1 , wherein said animal is a human. 
     
     
         9 . The method of  claim 1 , wherein said method comprises administering said polypeptide to said animal. 
     
     
         10 . The method of  claim 1 , wherein said method comprises administering said nucleic acid to said animal. 
     
     
         11 . The method of  claim 10 , wherein said nucleic acid is a viral vector encoding said polypeptide. 
     
     
         12 . The method of  claim 11 , wherein said viral vector is an adenoviral, vaccinia viral, measles, or adeno-associated virus vector. 
     
     
         13 . The method of  claim 1 , wherein said immune response reduces the severity of an infection within said animal. 
     
     
         14 . The method of  claim 1 , wherein said infection is a  Mycobacterium tuberculosis  infection. 
     
     
         15 . The method of  claim 1 , wherein said infection is a  Staphylococcus aureus  infection.