US2011189738A1PendingUtilityA1

Process for producing glutamate derivatives

Assignee: AJINOMOTO KKPriority: Dec 27, 2001Filed: Mar 10, 2011Published: Aug 4, 2011

Est. expiryDec 27, 2021(expired)· nominal 20-yr term from priority

Inventors:Masakazu Sugiyama Kunihiko Watanabe Nao Funakoshi Yusuke Amino Shigeru Kawahara Tadashi Takemoto

C12N 9/88C12P 7/50C12P 13/14C12P 13/04C12P 17/10

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Abstract

The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.

Claims

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1 . A method for producing 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid comprising
 contacting indole-3-pyruvate with a polypeptide chosen from 4-hydroxy-4-methyl-2-oxoglutarate aldolase and 4-hydroxy-2-oxoglutarate aldolase under conditions in which 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid is produced.

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