Benzimidazole modulators of vr1

Abstract

The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

1 . A compound of Formula (I): 
       
         
           
           
               
               
           
         
         and a salt, stereoisomer, tautomer or ester thereof, wherein: 
         the dashed lines between positions 1, 2 and 3 in Formula (I) indicate the positions of a tautomeric double bond, 
         wherein when a double bond is formed between positions 1 and 2, then R 3b  is present, and 
         wherein, when a double bond is formed between positions 2 and 3, then R 3a  is present; 
         p is 1 or 2; 
         q is 0 or 1; 
         r is 0, 1, 2 or 3; 
         L is C 1-3 alkyl; 
         A 1  is selected from the group consisting of phenyl, biphenyl, naphthyl, pyridinyl, quinolinyl and indole; 
         R 1  is each selected from the group consisting of hydroxy, cyano, halogen, formyl, carboxy, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-4 alkyl, C 3-8 cycloalkyl-C 1-4 alkoxy, C 3-8 cycloalkyl-oxy, amino, (C 1-6 alkyl) 1-2 amino, (C 3-8 cycloalkyl) 1-2 amino, (C 3-8 cycloalkyl-C 1-4 alkyl) 1-2 -amino, aminocarbonyl, (C 1-6 alkyl) 1-2 -aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, aminocarbonylamino, (C 1-6 alkyl) 1-2 -aminocarbonylamino, C 1-6 alkylsulfonylamino, C 1-6 alkylsulfinylamino, aminosulfonyl, (C 1-4 alkyl) 1-2 -aminosulfonyl, aminosulfonylamino and (C 1-6 alkyl) 1-2 -aminosulfonylamino, 
         wherein alkyl is optionally substituted with C 1-8 alkoxy, amino, (C 1-4 alkyl) 1-2 amino, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, aminocarbonylamino, (C 1-6 alkyl) 1-2 -aminocarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonylamino, (C 1-6 alkyl) 1-2 aminosulfonylamino hydroxy and phenyl, 
         wherein phenyl is optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, cyano, nitro, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio and C 1-6 alkylsulfonyl, and 
         wherein, each instance of alkyl and alkoxy is optionally perfluorinated; 
         R 2  is selected from the group consisting of halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylsulfonyl, nitro, amino, (C 1-4 alkyl) 1-2 amino and cyano, 
         wherein each instance of alkyl and alkoxy is optionally perfluorinated; 
         R 3a  and R 3b  are each selected from the group consisting of hydrogen and optionally perfluorinated C 1-4 alkyl; and 
         R 4  is each selected from the group consisting of halogen, nitro, cyano, carboxy, C 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylthio, haloC 1-6 alkylthio, C 1-6 alkylsulfonyl, haloC 1-6 alkylsulfonyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl-C 1-4 alkyl, C 3-8 cycloalkyl-C 1-4 alkoxy, C 3-8 cycloalkyl-oxy, amino, (C 1-6 alkyl) 1-2 amino, (C 3-8 cycloalkyl) 1-2 amino, (C 3-8 cycloalkyl-C 1-4 alkyl) 1-2 amino, aminocarbonyl, (C 1-6 alkyl) 1-2 aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, aminocarbonylamino, (C 1-6 alkyl) 1-2 aminocarbonylamino, C 1-6 alkylsulfonylamino, haloC 1-6 alkylsulfonylamino, C 1-6 alkylsulfinylamino, aminosulfonyl and (C 1-4 alkyl) 1-2 aminosulfonyl, 
         wherein each instance of alkyl is optionally substituted with one, two or three substituents independently selected from the group consisting of C 1-8 alkoxy, amino, (C 1-4 alkyl) 1-2 amino, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, aminocarbonylamino, (C 1-6 alkyl) 1-2 aminocarbonylamino, C 1-6 alkylsulfonylamino, oxo and hydroxy, and 
         wherein, each instance of alkyl and alkoxy is optionally perfluorinated. 
       
     
     
         2 . The compound of  claim 1 , wherein q is 0. 
     
     
         3 . The compound of  claim 1 , wherein A 1  is selected from the group consisting of phenyl, biphenyl, naphthyl, quinolinyl and indole. 
     
     
         4 . The compound of  claim 1 , wherein
 R 1  is each selected from the group consisting of hydroxy, halogen, formyl, C 1-6 alkyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, amino, aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, (C 1-4 alkyl) 1-2 aminosulfonyl and aminosulfonylamino,   wherein alkyl is optionally substituted with amino, (C 1-4 alkyl) 1-2 amino, aminosulfonylamino or hydroxy, and wherein, alkyl is optionally perfluorinated.   
     
     
         5 . The compound of  claim 1 , wherein R 2  is selected from the group consisting of halogen and C 1-4 alkyl, wherein alkyl is optionally perfluorinated. 
     
     
         6 . The compound of  claim 1 , wherein R 3a  and R 3b  are each selected from the group consisting of hydrogen and C 1-4 alkyl. 
     
     
         7 . The compound of  claim 1 , wherein R 4  is each selected from the group consisting of halogen, carboxy, C 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, haloC 1-6 alkylthio, C 1-6 alkylsulfonyl, haloC 1-6 alkylsulfonyl, (C 1-6 alkyl) 1-2 amino, (C 1-6 alkyl) 1-2 aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino and haloC 1-6 alkylsulfonylamino, wherein alkyl and alkoxy are optionally perfluorinated. 
     
     
         8 . The compound of  claim 1 , wherein
 p is 1 or 2;   q is 0;   r is 0, 1, 2 or 3;   L is C 1-3 alkyl;   A 1  is selected from the group consisting of phenyl, biphenyl, naphthyl, quinolinyl and indole;   R 1  is each selected from the group consisting of hydroxy, halogen, formyl, C 1-6 alkyl, haloC 1-6 alkyl, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkylthio, C 1-6 alkylsulfonyl, amino, aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkoxycarbonylamino, C 1-6 alkylsulfonylamino, aminosulfonyl, (C 1-4 alkyl) 1-2 aminosulfonyl and aminosulfonylamino,   wherein alkyl is optionally substituted with amino, (C 1-4 alkyl) 1-2 amino, aminosulfonylamino or hydroxy, and wherein, alkyl is optionally perfluorinated;   R 2  is selected from the group consisting of halogen and C 1-4 alkyl, wherein alkyl is optionally perfluorinated;   R 3a  and R 3b  are each selected from the group consisting of hydrogen and C 1-4 alkyl; and   R 4  is each selected from the group consisting of halogen, carboxy, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkylcarbonyl, haloC 1-6 alkylthio, C 1-6 alkylsulfonyl, haloC 1-6 alkylsulfonyl, (C 1-6 alkyl) 1-2 amino, (C 1-6 alkyl) 1-2 aminocarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkylsulfonylamino and haloC 1-6 alkylsulfonylamino, wherein alkyl and alkoxy are optionally perfluorinated.   
     
     
         9 . A compound selected from the group consisting of:
 2-{2-[3-(4-tert-butyl-phenyl)-propyl]-1H-benzimidazol-5-yl}-phenol,   2-[3-(4-tert-butyl-phenyl)-propyl]-5-m-tolyl-1H-benzimidazole,   N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   3-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   4-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   1-(2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   2-{2-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   1-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   1-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)ethanol,   N-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   1-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-(4-{2-[5-(2-acetyl-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-methanesulfonamide,   N-[4-(2-{5-[2-(1-hydroxy-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   N-(2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-(4-{2-[5-(2-acetyl-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   C,C,C-trifluoro-N-[4-(2-{5-[2-(1-hydroxy-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   C,C,C-trifluoro-N-(4-{2-[5-(2-methanesulfonylamino-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   2-{2-[2-(4-trifluoromethanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-{2-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,3,4-trifluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,4,5-trifluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,6-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,5-bis-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-chloro-2-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-chloro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,4-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,4-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,3-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,5-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,5-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-(2-phenethyl-1H-benzimidazol-5-yl)-benzenesulfonamide,   N,N-dimethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-methyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-fluoro-2-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-fluoro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-fluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-fluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-isopropyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   4-trifluoromethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   (E)-5-trifluoromethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   5-trifluoromethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   (E)-1-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-vinyl)-phenyl]-ethanone,   N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-acetamide,   2-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzylamine.   
     
     
         10 . The compound of  claim 9 , wherein the compound is selected from the group consisting of:
 2-{2-[3-(4-tert-butyl-phenyl)-propyl]-1H-benzimidazol-5-yl}-phenol,   2-[3-(4-tert-butyl-phenyl)-propyl]-5-m-tolyl-1H-benzimidazole,   N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   3-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   4-{2-[2-(4-tert-butyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenol,   1-(2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   2-{2-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-methyl-2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-fluoro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,3,4-trifluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,4,5-trifluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,6-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,5-bis-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-chloro-2-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-chloro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,4-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,4-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,3-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2,5-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3,5-difluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-(2-phenethyl-1H-benzimidazol-5-yl)-benzenesulfonamide,   N,N-dimethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-methyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-fluoro-2-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-fluoro-3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(2-fluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-fluoro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   2-{2-[2-(4-isopropyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   4-trifluoromethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   5-trifluoromethyl-2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   (E)-1-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-vinyl)-phenyl]-ethanone,   (E)-N-isopropyl-4-{2-[5-(2-methylsulfamoyl-phenyl)-1H-benzimidazol-2-yl]-vinyl}-benzamide,   N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-acetamide,   2-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   (E)-2-[2-(2-styryl-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzylamine,   2-[2-(2-phenylethynyl-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-phenylethynyl-1H-benzimidazol-5-yl)-benzenesulfonamide,   
     
     
         11 . The compound of  claim 9 , wherein the compound is selected from the group consisting of:
 C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethoxy-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   1-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   N-(2-{2-[2-(4-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   1-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   C,C,C-trifluoro-N-(2-{2-[2-(4-methanesulfonyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,2-trifluoro-1-trifluoromethyl-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanone,   1-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-ethanol,   N-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   2-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-propan-2-ol,   2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-benzenesulfonamide,   C,C,C-trifluoro-N-[2-(2-{2-[4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-ethyl}-1H-benzimidazol-5-yl)-phenyl]-methanesulfonamide,   1-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)ethanol,   N-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   N-(2-{2-[2-(3-chloro-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   1-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanone,   1-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-ethanol,   N-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   2-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol,   C,C,C-trifluoro-N-(2-{2-[2-(3-trifluoromethyl-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-(4-{2-[5-(2-acetyl-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-methanesulfonamide,   N-[4-(2-{5-[2-(1-hydroxy-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   N-(2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-methanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide,   N-(4-{2-[5-(2-acetyl-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-C,C,C-trifluoro-methanesulfonamide,   C,C,C-trifluoro-N-[4-(2-{5-[2-(1-hydroxy-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   C,C,C-trifluoro-N-(4-{2-[5-(2-methanesulfonylamino-phenyl)-1H-benzimidazol-2-yl]-ethyl}-phenyl)-methanesulfonamide,   C,C,C-trifluoro-N-[4-(2-{5-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-1H-benzimidazol-2-yl}-ethyl)-phenyl]-methanesulfonamide,   2-{2-[2-(4-trifluoromethanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-benzenesulfonamide,   C,C,C-trifluoro-N-(2-{2-[2-(4-trifluoromethanesulfonylamino-phenyl)-ethyl]-1H-benzimidazol-5-yl}-phenyl)-methanesulfonamide.   
     
     
         12 . A salt of the compound of  claim 1  selected from the group consisting of acetate, adipate, benzenesulfonate, benzoate, bicarbonate, bisulfate, bitartrate, borate, bromide, calcium, camsylate (or camphorsulphonate), carbonate, chloride, choline, clavulanate, citrate, dihydrochloride, disodium, edetate, fumarate, gluconate, glutamate, hydrabamine, hydrobromine, hydrochloride, iodide, isothionate, lactate, malate, maleate, mandelate, mesylate, nitrate, oleate, pamoate, palmitate, phosphate/diphosphate, salicylate, sodium, stearate, sulfate, succinate, tartrate, tromethane, tosylate, trichloroacetate and trifluoroacetate. 
     
     
         13 . The salt of  claim 12 , wherein the salt is selected from the group consisting of disodium, hydrochloride and sodium. 
     
     
         14 . A pharmaceutical composition comprising the compound of  claim 1  and one or more pharmaceutically acceptable carriers, excipients or diluents. 
     
     
         15 .- 20 . (canceled)