Methods for treating glioblastoma with herbal compositions

Abstract

The inventive subject matter relates to methods for treating glioblastoma, comprising administration of a composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric, Scutellaria baicalensis , rosemary, green tea, huzhang, Chinese goldthread, and barberry. The inventive subject matter further relates to methods for modulating gene expression of genes selected from the group consisting of interleukin-1α, interleukin-1β, heme oxygenase 1, aldo-keto reductase family 1, member C2, colony stimulating factor 3, leukemia inhibitory factor, heat shock 70 kDa protein, and combinations thereof, by administration of an effective amount of said compositions.

1 - 22 . (canceled) 
     
     
         23 . A method for treating at least one cancerous tumor of the central nervous system in a subject in need thereof, comprising the step of administering an effective amount of a composition to said subject sufficient to treat said tumor, said composition comprising therapeutically effective amounts of supercritical extracts of rosemary, turmeric, oregano and ginger; and therapeutically effective amounts of hydroalcoholic extracts of holy basil, ginger, turmeric,  Scutellaria baicalensis , rosemary, green tea, huzhang, Chinese goldthread, and barberry. 
     
     
         24 . The method of  claim 23 , wherein said composition is administered orally. 
     
     
         25 . The method of  claim 24 , wherein the orally administered composition is in the form of one or more capsules, one or more tablets, or one or more pills. 
     
     
         26 . The method of  claim 23 , wherein the composition comprises:
 (A) from about 4.5% to about 7.5% by weight of the hydroalcoholic extract of ginger;   (B) from about 5.5% to about 8.5% by weight of the supercritical extract of ginger;   (C) from about 1.0% to about 1.5% by weight of the supercritical extract of turmeric;   (D) from about 10.0% to about 16.0% by weight of the supercritical extract of rosemary;   (E) from about 4.0% to about 6.0% by weight of the supercritical extract of oregano;   (F) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of turmeric;   (G) from about 5.5% to about 8.0% by weight of the hydroalcoholic extract of rosemary;   (H) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of holy basil;   (I) from about 10.0% to about 16.0% by weight of the hydroalcoholic extract of green tea;   (J) from about 8.0% to about 12.0% by weight of the hydroalcoholic extract of huzhang;   (K) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of Chinese goldthread;   (L) from about 4.0% to about 6.0% by weight of the hydroalcoholic extract of barberry; and   (M) from about 2.0% to about 3.0% by weight of the hydroalcoholic extract of  Scutellaria baicalensis.      
     
     
         27 . The method of  claim 23 , wherein said at least one cancerous tumor is detected during surgery on the central nervous system of said subject, having not been felt by a physician on physical examination of said subject. 
     
     
         28 . The method of  claim 23 , wherein said at least one cancerous tumor is confined to the central nervous system of said subject and is detected by a physician on physical examination of said subject. 
     
     
         29 . The method of  claim 23 , wherein cancer related to said at least one cancerous tumor extends beyond the central nervous system of said subject, but has not spread to lymph nodes in said subject 
     
     
         30 . The method of  claim 23 , wherein cancer related to said at least one cancerous tumor is metastasized to regional lymph nodes or other parts of said subject.