Fluid-jet medicament delivery

Abstract

A method of applying an orally-ingestible medicament to an orally-ingestible carrier comprising the steps of controlling a relative position between a fluid ejector and the carrier, and ejecting a plurality of drops of solution onto the carrier, wherein the plurality of drops includes a desired therapeutic quantity of the orally-ingestible medicament.

1 . An interactive system comprising:
 a medicament dispensing assembly including a drop firing controller, fluid drop ejectors and an ingestible sheet transporter;   a network interface; and   a processor coupled to said network interface and to said dispensing assembly, wherein said processor determines a customized medicament dose for a specific individual based on information received across the network from a remote provider, and   wherein said medicament dispensing assembly dispenses medicament fluid drops onto the ingestible sheet based on the customized dose.   
     
     
         2 . The interactive system of  claim 1 , further comprising a provider interface coupled to the network. 
     
     
         3 . The interactive system of  claim 1 , further comprising multiple provider interfaces coupled to the network. 
     
     
         4 . The interactive system of  claim 1 , wherein the information comprises information about the individual, a provider sending the signal, or a medicament dosage, or a combination of any of those. 
     
     
         5 . The interactive system of  claim 4 , wherein the information about the individual comprises current health information. 
     
     
         6 . The interactive system of  claim 4 , wherein the information about a medicament dosage comprises a quantity or dose of the medicament to be dispensed. 
     
     
         7 . The interactive system of  claim 4 , wherein the information about the provider comprises an authorization code verifying the authority of the provider to dispense the medicament. 
     
     
         8 . The interactive system of  claim 4 , wherein the provider is a health care provider. 
     
     
         9 . A system comprising:
 means for determining a medicament dosage customized for a specific individual;   means for dispensing a medicament onto an ingestible sheet based on the customized medicament dosage; and   means for forming a customized dosage form from said ingestible sheet containing said medicament.   
     
     
         10 . An interactive method of generating a dosage form that is customized for a specific individual, comprising:
 (a) loading a medicament and an ingestible sheet into the medicament dispensing system of  claim 1 ;   (b) receiving from a remote provider a signal comprising information to be utilized by the medicament dispensing system;   (c) determining, by the processor, a customized dosage for the individual based on the received signal;   (d) dispensing, by the medicament dispensing system, medicament fluid drops onto the ingestible sheet based on the customized dose; and   (e) forming the ingestible sheet containing the customized dosage into a dosage form.   
     
     
         11 . The interactive method of  claim 10 , wherein (d) and (e) are performed in a home, pharmacy, hospital or supermarket. 
     
     
         12 . The interactive method of  claim 10 , wherein in (b), receiving said signal from a remote provider comprises transmitting the signal over the network. 
     
     
         13 . The interactive method of  claim 10 , wherein (c) comprises verifying the information received from a remote provider. 
     
     
         14 . The interactive method of  claim 13 , wherein said verifying comprises verifying that the quantity or dose of the medicament received in (b) is in a correct range. 
     
     
         15 . The interactive method of  claim 13 , wherein said verifying comprises comparing information written on said ingestible sheet to information received in (b). 
     
     
         16 . The interactive method of  claim 10 , comprising dispensing the medicament onto the ingestible sheet, and dispensing an edible barrier material over the medicament. 
     
     
         17 . The interactive method of  claim 10 , comprising dispensing two different medicaments onto the ingestible sheet. 
     
     
         18 . The interactive method of  claim 10 , comprising printing user information on the ingestible sheet using an ingestible ink. 
     
     
         19 . The interactive method of  claim 10 , wherein said ingestible sheet is adhered to a releasable backing. 
     
     
         20 . The interactive method of  claim 10 , wherein said ingestible sheet comprises a dosage region comprising a first edge and a second edge, and in (d), dispensing the customized dosage onto the ingestible sheet includes ejecting a two-dimensional droplet array of the medicament onto the dosage region to form a density gradient of medicament dots between said first and second edges, wherein either the first or second edge has a greater density of medicament dots than the other edge, and
 wherein, in (e), forming the ingestible sheet containing the customized dosage into a dosage form includes winding the sheet into a coil.