US2011206691A1PendingUtilityA1

Methods and Compositions for Treating Neuroblastoma

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Individually held — no corporate assignee on recordPriority: Feb 15, 2008Filed: Mar 25, 2011Published: Aug 25, 2011
Est. expiryFeb 15, 2028(~1.5 yrs left)· nominal 20-yr term from priority
Inventors:Yael P. MosseErica L. Carpenter
A61K 39/3955C12Q 2600/106A61K 2039/505C07K 2317/73C12Q 2600/136C12Q 2600/172C07K 16/40A61K 31/4545C07K 2317/732A61P 35/00C12Q 1/6886
34
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Claims

Abstract

Methods and compositions for treating neuroblastoma are disclosed.

Claims

exact text as granted — not AI-modified
1 . A method for inhibiting neuroblastoma in a subject comprising the administration of at least one composition comprising at least one ALK antibody and at least one pharmaceutically acceptable carrier. 
     
     
         2 . The method of  claim 1 , wherein said ALK antibody is immunologically specific for the extracellular domain of ALK. 
     
     
         3 . The method of  claim 1 , wherein said neuroblastoma is resistant to at least one ALK inhibitor. 
     
     
         4 . The method of  claim 1 , wherein said neuroblastoma is resistant to crizotinib. 
     
     
         5 . The method of  claim 1 , further comprising the administration of at least one composition comprising at least one ALK inhibitor and at least one pharmaceutically acceptable carrier. 
     
     
         6 . The method of  claim 5 , wherein said ALK inhibitor is a small molecule inhibitor. 
     
     
         7 . The method of  claim 6 , wherein said ALK inhibitor is crizotinib. 
     
     
         8 . A kit comprising a first composition comprising at least one ALK antibody and at least one pharmaceutically acceptable carrier and a second composition comprising at least one ALK inhibitor and at least one pharmaceutically acceptable carrier.

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