US2011207914A1PendingUtilityA1

Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses

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Assignee: AMBRX INCPriority: Sep 8, 2006Filed: Feb 25, 2011Published: Aug 25, 2011
Est. expirySep 8, 2026(~0.1 yrs left)· nominal 20-yr term from priority
Inventors:Joseph ShefferThea NormanRichard D. DimarchiAnna-Maria A. Hays PutnamFeng TianStephanie ChuDenise KrawitzHo Sung Cho
C07K 14/765C07K 14/62A61P 43/00C07K 2319/00C07K 19/00C07K 14/575A61K 38/00C07K 14/47C07K 14/435A61K 38/17A61P 7/00
61
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Claims

Abstract

Modified human plasma polypeptides or Fc and uses thereof are provided.

Claims

exact text as granted — not AI-modified
1 - 76 . (canceled) 
     
     
         77 . An hPP or hFc comprising one or more non-naturally encoded amino acids linked to apolipoprotein. 
     
     
         78 . The hPP or hFC of  claim 77 , wherein the hPP or hFc further comprises one or more peptides selected from the group consisting of preproinsulin, proinsulin, or pancreatic hormones. 
     
     
         79 . The hPP or hFC of  claim 78 , wherein the pancreatic hormone is selected from the group consisting of insulin, insulin-like peptides, glucagon, somatostatin, pancreatic polypeptides, amylin, peptide YY, and neuropeptide Y.

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