Methods for the diagnosis and treatment of bone disorders

Abstract

This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

1 - 187 . (canceled) 
     
     
         188 . A composition rich in proline, and/or free proline, and/or one or more proline precursors, for the treatment of and/or the prevention of a condition associated with a bone disorder. 
     
     
         189 . A dietary supplement rich in proline, and/or free proline, and/or one or more proline precursors, for use in the treatment of and/or the prevention of a condition associated with a bone disorder. 
     
     
         190 . A method of treatment of and/or the prevention of a condition associated with a bone disorder comprising administration of a composition rich in proline, and/or free proline, and/or one or more proline precursors according to  claim 188 . 
     
     
         191 . (canceled) 
     
     
         192 . Use of a composition rich in proline, and/or free proline, and/or one or more proline precursors according to  claim 188  in the preparation of a medicament for the treatment of and/or the prevention of a condition associated with a bone disorder. 
     
     
         193 . (canceled) 
     
     
         194 . A composition according to  claim 188 , wherein said treatment is by oral administration. 
     
     
         195 - 196 . (canceled) 
     
     
         197 . A composition according to  claim 188 , wherein said “proline, and/or free proline, and/or one or more proline precursors” is proline. 
     
     
         198 - 199 . (canceled) 
     
     
         200 . A method of therapy of a condition associated with a bone disorder based upon correction of metabolic defect in one or more of (a) proline synthesis, (b) proline transport, (c) proline absorption, and (d) proline loss mechanisms. 
     
     
         201 . A method of treatment of a condition associated with proline deficiency, comprising chronic administration of paracetamol. 
     
     
         202 . Use of paracetamol according to the method of  claim 201  in the preparation of a medicament for the treatment of a condition associated with proline deficiency. 
     
     
         203 . A method of therapeutic monitoring of the treatment of a patient having a condition associated with a bone disorder comprising monitoring proline levels in said patient. 
     
     
         204 . A genetic test for susceptibility to conditions associated with a bone disorder based upon polymorphisms of enzymes involved in proline metabolism. 
     
     
         205 . Use of an enzyme involved in proline metabolism, and/or an associated compound, as a target for the identification of a compound which is useful in the treatment of a condition associated with a bone disorder. 
     
     
         206 . A method of identifying a compound which is useful in the treatment of a condition associated with a bone disorder, and which employs an enzyme involved in proline metabolism and/or an associated compound, as a target, used according to the use of  claim 205 . 
     
     
         207 - 210 . (canceled) 
     
     
         211 . A method of genetically modifying an animal so as to have a deficiency in circulating free proline. 
     
     
         212 . A genetically modified animal prepared according to a method of  claim 211 . 
     
     
         213 . Use of an animal prepared according to a method of  claim 211  for the development and/or testing of a treatment or therapy.