Ophthalmic and contact lens solutions containing peptides as preservative

Abstract

A method and a contact lens solution comprising 0.001 to 10 weight percent or a preservative enhancer chosen from the group consisting of: SEQ ID NO.1 and SEQ ID NO. 2; and at least 0.0001 weight percent of a preservative agent, and where the concentration of chloride in said solution is less than 0.2 percent by weight.

1 . An ophthalmic solution comprising 0.001 to 10 weight percent of a peptide chosen from the group consisting of SEQ ID NO.1 and SEQ ID NO. 2; and at least 0.0001 weight percent of a preservative agent, and where the concentration of chloride in said solution is less than 0.2 percent by weight. 
     
     
         2 . The solution of  claim 1 , wherein said preservative agent is a cationic polymeric preservative having a concentration between 1 and 100 parts per million. 
     
     
         3 . The solution of  claim 1 , further comprising a physiologically compatible buffer selected from the group consisting of phosphate, bicarbonate, citrate, borate, ACES, BES, BICINE, BIS, BIS-Tris, BIS-Tris Propane, HEPES, HEPPS, imidazole, Tris, MES, MOPS, PIPES, TAPS, TES, Glycine and Tricine. 
     
     
         4 . The solution of  claim 1 , further comprising between 0.01% and 5.0% glycerin. 
     
     
         5 . The solution of  claim 1  further comprising between 0.01% and 2.0% of decanedioic acid. 
     
     
         6 . The solution of  claim 1  further comprising a wetting agent selected from the group consisting of polysorbate surfactants, polyoxyethylene surfactants, phosphonates, saponins and polyethoxylated castor oils. 
     
     
         7 . The solution of  claim 1  further comprising a sequestering agent selected from the group consisting as ethylenediaminetetraacetic acid, phosphonates, citrate, gluconate and tartarate. 
     
     
         8 . The solution of  claim 1 , wherein the concentration of chloride in said solution is not more than 0.2 mole percent. 
     
     
         9 . The solution of  claim 1 , wherein said solution has a pH between 6.0 and 8.0. 
     
     
         10 . The solution of  claim 2 , wherein said cationic polymeric preservative is polyhexamethylene biguanide. 
     
     
         11 . A method for wetting a contact lens comprising the steps of:
 providing a contact lens; and   contacting said contact lens with a solution comprising 0.001 to 10 weight percent of peptide chosen from the group consisting of SEQ ID NO. 1 and SEQ ID NO. 2; and at least 0.0001 weight percent of a preservative agent, and where the concentration of chloride in said solution not more than 0.2 percent by weight.   
     
     
         12 . The method of  claim 11 , wherein said preservative agent is a cationic polymeric preservative having a concentration between 1 and 100 parts per million. 
     
     
         13 . The method of  claim 12 , wherein said cationic polymeric preservative is polyhexamethylene biguanide. 
     
     
         14 . The method of  claim 11 , wherein said solution further comprises a physiologically compatible buffer selected from the group consisting of phosphate, bicarbonate, citrate, borate, ACES, BES, BICINE, BIS, BIS-Tris, BIS-Tris Propane, HEPES, HEPPS, imidazole, Tris, MES, MOPS, PIPES, TAPS, TES, Glycine and Tricine. 
     
     
         15 . The method of  claim 11 , wherein said solution has a pH between 6.0 and 8.0. 
     
     
         16 . A method for delivering an ophthalmic solution to the eye comprising the steps of:
 providing a bottle comprising a solution comprising 0.001 to 10 weight percent of peptide chosen from the group consisting of SEQ ID NO. 1 and SEQ ID NO. 2; and at least 0.0001 weight percent of a preservative agent, and where the concentration of chloride in said solution not more than 0.2 percent by weight; and   delivering said solution form said bottle to an eye such that the solution comes in direct contact with corneal tissue.   
     
     
         17 . The method of  claim 16 , wherein said preservative agent is a cationic polymeric preservative having a concentration between 1 and 100 parts per million. 
     
     
         18 . The method of  claim 17 , wherein said cationic polymeric preservative is polyhexamethylene biguanide. 
     
     
         19 . The method of  claim 16 , wherein said solution further comprises a physiologically compatible buffer selected from the group consisting of phosphate, bicarbonate, citrate, borate, ACES, BES, BICINE, BIS, BIS-Tris, BIS-Tris Propane, HEPES, HEPPS, imidazole, Tris, MES, MOPS, PIPES, TAPS, TES, Glycine and Tricine. 
     
     
         20 . The method of  claim 16 , wherein said solution has a pH between 6.0 and 8.0.