3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands

Abstract

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

1 - 157 . (canceled) 
     
     
         158 . A method of treating COPD, comprising administering an effective amount of the compound 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof to a patient in need of such treatment. 
     
     
         159 . A pharmaceutical composition, comprising the compound 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is a capsule.