Combinations for the treatment of immunoinflammatory disorders

Abstract

The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.

1 . A method of reducing the levels of TNFα in mammalian blood, comprising contacting cells in the blood with a composition consisting of a corticosteroid, dipyridamole, and excipients. 
     
     
         2 . The method of  claim 1 , wherein the method suppresses the secretion of TNFα. 
     
     
         3 . The method of  claim 1 , wherein the cells have been stimulated to secrete TNFα. 
     
     
         4 . The method of  claim 3  wherein the cells comprise white blood cells. 
     
     
         5 . The method of  claim 1 , further comprising the step of confirming the reduction in TNFα levels. 
     
     
         6 . The method of  claim 5 , wherein the confirming step comprises the use of an antibody or an antibody-based assay. 
     
     
         7 . The method of  claim 6  wherein the antibody-based assay is an ELISA. 
     
     
         8 . The method of  claim 1 , wherein said corticosteroid is algestone, 6-alpha-fluoroprednisolone, 6-alpha-methylprednisolone, 6-alpha-methylprednisolone 21-acetate, 6-alpha-methylprednisolone 21-hemisuccinate sodium salt, 6-alpha,9-alpha-difluoroprednisolone 21-acetate 17-butyrate, amcinafal, beclomethasone, beclomethasone dipropionate, beclomethasone dipropionate monohydrate, 6-beta-hydroxycortisol, betamethasone, betamethasone-17-valerate, budesonide, clobetasol, clobetasol propionate, clobetasone, clocortolone, clocortolone pivalate, cortisone, cortisone acetate, cortodoxone, deflazacort, 21-deoxycortisol, deprodone, descinolone, desonide, desoximethasone, dexamethasone, dexamethasone-21-acetate, dichlorisone, diflorasone, diflorasone diacetate, diflucortolone, doxibetasol, fludrocortisone, flumethasone, flumethasone pivalate, flumoxonide, flunisolide, fluocinonide, fluocinolone acetonide, 9-fluorocortisone, fluorohydroxyandrostenedione, fluorometholone, fluorometholone acetate, fluoxymesterone, flupredidene, fluprednisolone, flurandrenolide, formocortal, halcinonide, halometasone, halopredone, hyrcanoside, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone cypionate, hydrocortisone sodium phosphate, hydrocortisone sodium succinate, hydrocortisone probutate, hydrocortisone valerate, 6-hydroxydexamethasone, isoflupredone, isoflupredone acetate, isoprednidene, meclorisone, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, paramethasone, paramethasone acetate, prednisolone, prednisolone acetate, prednisolone metasulphobenzoate, prednisolone sodium phosphate, prednisolone tebutate, prednisolone-21-hemisuccinate free acid, prednisolone-21-acetate, prednisolone-21(beta-D-glucuronide), prednisone, prednylidene, procinonide, tralonide, triamcinolone, triamcinolone acetonide, triamcinolone acetonide 21-palmitate, triamcinolone diacetate, or triamcinolone hexacetonide. 
     
     
         9 . The method of  claim 8 , wherein said corticosteroid is prednisone or prednisolone. 
     
     
         10 . The method of  claim 9 , wherein said composition comprises 0.5 to 10 mg of prednisone or prednisolone. 
     
     
         11 . The method of  claim 9 , wherein said composition comprises 100 to 400 mg of dipyridamole. 
     
     
         12 . The method of  claim 1 , wherein said composition comprises 100 to 400 mg of dipyridamole. 
     
     
         13 . The method of  claim 1 , wherein said composition comprises 0.5 to 10 mg corticosteroid. 
     
     
         14 . The method of  claim 13 , wherein said composition comprises 0.5 to 10 mg corticosteroid and 100 to 400 mg of dipyridamole.