Method for diagnosing non-small cell lung cancer

Abstract

Disclosed are methods for detecting non-small cell lung cancer (NSCLC) using differentially expressed genes KIF11, GHSR1b, NTSR1, and FOXM1. Also disclosed are methods of identifying compounds for treating and preventing NSCLC, based on the interaction between KOC1 and KIF11, or NMU and GHSR1b or NTSR1.

1 . A method of screening for a compound for treating or preventing NSCLC, said method comprising the steps of:
 contacting a KIF11 polypeptide or functional equivalent thereof with KOC1 polypeptide or functional equivalent thereof in the presence of a test compound;   detecting the binding between the polypeptides; and   selecting the test compound that inhibits the binding between the polypeptides.   
     
     
         2 . The method of  claim 1 , wherein the functional equivalent of KIF11 polypeptide comprises amino acid sequence of KOC1 binding domain. 
     
     
         3 . The method of  claim 1 , wherein the functional equivalent of KOC1 polypeptide comprises amino acid sequence of KIF11 binding domain.