US2011224213A1PendingUtilityA1

Use of Glutaric Acid Derivatives or the Pharmaceutically Acceptable Salts Thereof as Anti-Arrhythmic Agents

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Assignee: NEBOLSIN VLADIMIR EVGENIEVICHPriority: Mar 19, 2008Filed: Mar 18, 2009Published: Sep 15, 2011
Est. expiryMar 19, 2028(~1.6 yrs left)· nominal 20-yr term from priority
Inventors:Vladimir Evgenievich NebolsinDmitry BlinovVladimir Pavlovich BalashovTatyana Alexandrovna KromovaGalina Alexandrovna Zheltukhina
C07D 295/13A61K 31/4172C07D 233/64C07D 209/20C07D 333/20A61K 31/405C07D 207/09A61P 9/06C07D 213/40
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Claims

Abstract

The invention relates to the use of glutaric acid derivatives of general formula (I), which are disclosed in the invention description, as anti-arrhythmic agents.

Claims

exact text as granted — not AI-modified
1 . Use of compounds of general formula (I): 
       
         
           
           
               
               
           
         
       
       wherein 
       
         
           
           
               
               
           
         
         R 2 =COOH, —COOCH 3 , —COOC 2 H 5 , H, 
       
       or a pharmaceutically acceptable salt thereof as an anti-arrhythmic agent. 
     
     
         2 . Use of compounds of general formula (I): 
       
         
           
           
               
               
           
         
       
       wherein 
       
         
           
           
               
               
           
         
         R 2 =COOH, —COOCH 3 , —COOC 2 H 5 , H, 
       
       or a pharmaceutically acceptable salt thereof for the production of a medicament having anti-arrhythmic activity. 
     
     
         3 . A pharmaceutical composition having anti-arrhythmic activity, comprising a compound of general formula (I): 
       
         
           
           
               
               
           
         
       
       wherein 
       
         
           
           
               
               
           
         
         R 2 =COOH, —COOCH 3 , —COOC 2 H 5 , H, 
       
       or a pharmaceutically acceptable salt thereof in an effective amount and a pharmaceutically acceptable carrier. 
     
     
         4 . A medicament having anti-arrhythmic activity, comprising a compound of general formula (I): 
       
         
           
           
               
               
           
         
       
       wherein 
       
         
           
           
               
               
           
         
         R 2 =COOH, —COOCH 3 , —COOC 2 H 5 , H, 
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         5 . A method of treating arrhythmia comprising administering to a mammal an effective amount of a compound of general formula (I): 
       
         
           
           
               
               
           
         
       
       wherein 
       
         
           
           
               
               
           
         
         R 2 =COOH, —COOCH 3 , —COOC 2 H 5 , H, 
       
       or a pharmaceutically acceptable salt thereof.

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