Catechol-based derivatives for treating or preventing diabetics

Abstract

The present invention provides a catechol-based derivative and a pharmaceutical acceptable salt therefrom and a solvate therefrom. A pharmaceutical composition for preventing or treating diabetes and ischemia, comprising a catechol-based derivative of formula (I) and at least one selected from the group consisting of a pharmaceutical excipient, a diluent and a carrier.

1 . A catechol-based derivative being one of a compound of a formula (I) and a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
         wherein R 1  and R 2  are independently selected from the group consisting of H, —OR, —NO 2 , —NH 2 , and a halogen; 
         R in the —OR is one selected from the group consisting of H, (C 1 -C 6 )alkyl, (CH 2 ) n Ph, SO 3 ″ and Ar; 
         R 3  is one of O and S; 
         R 4  is N; 
         X and Y are selected from the group consisting of alkyl, alkenyl, alkynyl, and —OCH 2 —; 
         R 5  is one selected from the group consisting of H, (C 1 -C 15 )alkyl, (CH 2 ) n Ar and Ar, wherein the n is an integer from 1 to 3; and 
         R 6  is one of H and (C 1 -C 6 ) alkyl. 
       
     
     
         2 . The catechol-based derivative as claimed in  claim 1 , wherein the two R 1  substituents of the benzene ring form a structure of: 
       
         
           
           
               
               
           
         
       
     
     
         3 . The catechol-based derivative as claimed in  claim 2 , wherein Ar is capable of being substituted by one selected from the group consisting of 
       
         
           
           
               
               
           
         
         and a heteroaryl group; 
         wherein R 7 , R 8 , R 9  are selected from the group consisting of H, —OH, —OCH 3 , —NO 2 , —NH 2 , —NH 3   + , and a halogen; and 
         X −  represents one of an organic alkali and an inorganic alkali. 
       
     
     
         4 . A pharmaceutical composition for treating diabetes, comprising a catechol-based derivative of  claim 1  and at least one selected from the group consisting of a pharmaceutical excipient, a diluent and a carrier. 
     
     
         5 . A pharmaceutical composition for treating an ischemia, comprising a catechol-based derivative of  claim 1  and at least one selected from the group consisting of a pharmaceutical excipient, a diluent and a carrier.