Diene compounds for use in human epidermal cell repair and pharmaceutical and cosmetic compositions containing them

Abstract

The present invention relates to a novel use of compounds having the general formula (I): CH 3 (—CH═CH) n —R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) , where R′ is chosen from among H, the alkyl from C 1 to C 22 , each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

1 . A pharmaceutical or cosmetic composition to improve cell repairing activity of the human epidermis through a keratin production mediated by cytokeratins cK-19, comprising as active principle a compound having general formula (I):
   CH 3 (—CH═CH) n —R  (I)
   wherein n=2-7,   R is selected among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) ,   wherein R′ is selected among H, alkyl from C 1  to C 22 ,   each compound of general formula (I) being used as such or in a mixture thereof.   
     
     
         2 . (canceled) 
     
     
         3 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrien-1-ol. 
     
     
         4 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrienoic acid. 
     
     
         5 . The composition according to  claim 1  wherein the said active principle is a pharmacologically or cosmetically acceptable salt of 2,4,6-octatrienoic acid. 
     
     
         6 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrienoic acid sodium salt. 
     
     
         7 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrienoic acid L-lysine salt. 
     
     
         8 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrienoic acid ethylester. 
     
     
         9 . The composition according to  claim 1  wherein the said active principle is 2,4,6-octatrien-1-ol, acetate. 
     
     
         10 . Composition according to  claim 1  wherein the said active principle is 2,4,6-octatrien-1-ol, palmitate. 
     
     
         11 . The composition according to  claim 1  wherein the said active principle is a mixture of two or more of the compounds of formula (I). 
     
     
         12 . The composition according to  claim 1  comprising an amount of the said active principle in the range 0.05-0.3% by weight. 
     
     
         13 . The composition according to  1  comprising the said active principle with any suitable excipient for a topical administration onto the skin.