Compositions and kits for treating influenza

Abstract

Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.

1 . A method of preventing or treating influenza comprising administering to a patient a therapeutically effective amount of a combination of first, second and third antiviral agents comprising:
 a) an M2 inhibitor;   b) a second antiviral agent selected from the group consisting of a replication inhibitor, an IMP dehydrogenase inhibitor and an RNA polymerase inhibitor; and   c) a neuraminidase inhibitor (NAi); and   wherein the combination increases the in vitro sensitivity of one or more strains of an influenza A virus to at least one of the antiviral agents by at least two fold.