US2011245226A1PendingUtilityA1

Piperidinyl derivatives as modulators of chemokine receptor activity

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Assignee: BRISTOL MYERS SQUIBB COPriority: Jan 27, 2006Filed: Jun 8, 2011Published: Oct 6, 2011
Est. expiryJan 27, 2026(expired)· nominal 20-yr term from priority
Inventors:Percy H. CarterCullen L. CavallaroJohn V. DunciaDaniel S. GardnerJohn HynesRui-Qin LiuJoseph B. SantellaDharmpal S. Dodd
A61P 37/00A61P 37/02A61P 37/08A61P 35/00A61P 37/06A61P 9/00A61P 31/18A61P 9/04A61P 9/10A61P 25/28A61P 29/00A61P 25/00A61P 17/06A61P 1/16A61P 1/04A61P 19/00A61P 13/12A61P 11/00A61P 19/10A61P 19/02A61P 11/06C07D 211/38C07D 401/12C07D 471/04C07D 417/12C07D 211/52C07D 211/58C07D 487/04C07D 417/14C07D 211/70C07D 491/10C07D 405/12C07D 491/107C07D 413/12C07D 401/14C07D 409/12C07D 211/18C07D 211/14
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Claims

Abstract

The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.

Claims

exact text as granted — not AI-modified
1 . A compound of Formula (I): 
       
         
           
           
               
               
           
         
         or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein: 
         the dashed line represents an optional double bond; 
         T is 
       
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, or alkenyl, wherein the alkyl may be optionally substituted with —OH; 
         R 3 , at each occurrence, is alkyl; or any two R 3 's attached to the same carbon atom may form a 3- to 6-membered ring; 
         W is hydrogen, F, —OH, —CN, —NH 2 ; 
         R 5  is halo, —CN or —Oalkyl; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-3; and 
         r is 0-5. 
       
     
     
         2 . The compound of  claim 1 , wherein the compound is a compound of formula (Ia): 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound of  claim 2 , wherein:
 T is   
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, or alkenyl, wherein the alkyl may be optionally substituted with —OH; 
         R 3 , at each occurrence, is alkyl; or any two R 3 's attached to the same carbon atom may form a 3- to 6-membered ring; 
         W is hydrogen, F, —OH, —NH 2 ; 
         R 5  is halo, —CN or —Oalkyl; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-2; and 
         r is 0-4. 
       
     
     
         4 . The compound of  claim 2 , wherein:
 T is   
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, or cycloalkylalkyl, wherein the alkyl may be optionally substituted with —OH; 
         R 3 , at each occurrence, is alkyl; or any two R 3 's attached to the same carbon atom may form a 3- to 6-membered ring; 
         W is hydrogen, F, —OH, —NH 2 ; 
         R 5  is halo or —CN; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-2; and 
         r is 0-3. 
       
     
     
         5 . The compound of  claim 2 , wherein:
 T is   
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl or cycloalkyl, wherein the alkyl may be optionally substituted with —OH; 
         R 3 , at each occurrence, is alkyl; or any two R 3 's attached to the same carbon atom may form a 3- to 6-membered ring; 
         W is hydrogen, F, —OH, —NH 2 ; 
         R 5  is halo; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-2; and 
         r is 0-2. 
       
     
     
         6 . A compound of Formula (Ib): 
       
         
           
           
               
               
           
         
         or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein 
         T is 
       
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, arylalkyl, —CH 2 CH 2 CH 2 NHC(═NR 14 )NR 14 R 14 , —CH 2 CH 2 S(CR 8 R 8 ) r R 10  or —CH 2 CH 2 CN, wherein the alkyl and arylalkyl may be optionally substituted with —OH; 
         R 4 , at each occurrence, is F, —OH or alkyl; or any two alkyl R 4 's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S; 
         W is hydrogen, F, —OH, —CN, —NH 2 ; 
         R 5  is halo, —CN or —Oalkyl; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; and 
         r is 0-5. 
       
     
     
         7 . The compound of  claim 6 , wherein the compound is a compound of formula (Ib′): 
       
         
           
           
               
               
           
         
         wherein 
         T is 
       
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, —CH 2 CH 2 CH 2 —NHC(═NH)NH 2 , —CH 2 CH 2 SCH 3 , —CH 2 CH 2 CN, 
       
       
         
           
           
               
               
           
         
       
       wherein the alkyl may be optionally substituted with —OH;
 R 4 , at each occurrence, is —OH or alkyl; or any two alkyl R 4 's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S; 
 W is hydrogen or OH; 
 R 5  is halo, —CN or —Oalkyl; 
 R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
 R 8 , at each occurrence, is independently hydrogen or alkyl; 
 R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
 m is 1 or 2; and 
 r is 0-4. 
 
     
     
         8 . The compound of  claim 7 , wherein:
 T is   
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, —CH 2 CH 2 SCH 3 , —CH 2 CH 2 CN, 
       
       
         
           
           
               
               
           
         
       
       wherein the alkyl may be optionally substituted with —OH;
 R 4 , at each occurrence, is —OH or alkyl; or any two alkyl R 4 's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S; 
 R 5  is halo or —CN; 
 R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
 R 8 , at each occurrence, is independently hydrogen or alkyl; 
 R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; and 
 r is 0-3. 
 
     
     
         9 . The compound of  claim 7 , wherein:
 T is   
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, 
       
       
         
           
           
               
               
           
         
       
       wherein the alkyl may be optionally substituted with —OH;
 R 4 , at each occurrence, is alkyl; or any two alkyl R 4 's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S; 
 R 5  is halo; 
 R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
 R 8 , at each occurrence, is independently hydrogen or alkyl; 
 R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
 R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
 R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; and 
 r is 0-2. 
 
     
     
         10 . The compound of  claim 7 , wherein R 2  is isopropyl, sec-butyl or cyclopropyl; R 4  is methyl; R 5  is Cl, F or Br; and R 1  is alkyl, cycloalkyl, aryl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a . 
     
     
         11 . The compound of  claim 10 , wherein:
 T is   
       
         
           
           
               
               
           
         
       
     
     
         12 . A compound of formula (Ic): 
       
         
           
           
               
               
           
         
         or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein: 
         R 15  is —NHR 1 , heteroaryl or aryl, wherein the heteroaryl and aryl may be optionally substituted with 0-3 R 1a ; 
         R 1  is aryl or heteroaryl, both of which may be optionally substituted with 0-3 R 1a , provided that when R 1  is phenyl, R 1a  cannot be ortho-methoxy; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl or cycloalkylalkyl, wherein the alkyl may be optionally substituted with —OH; 
         R 4 , at each occurrence, is F, —OH or alkyl; or any two alkyl R 4 's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S; 
         W is hydrogen, F, —OH or —NH 2 ; 
         R 5  is halo, —CN or —Oalkyl; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the l[k′ aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-3; and 
         r is 0-5. 
       
     
     
         13 . The compound of  claim 12 , wherein the compound is a compound of formula (Id): 
       
         
           
           
               
               
           
         
       
     
     
         14 . A compound of Formula (Ie): 
       
         
           
           
               
               
           
         
         or stereoisomers or pharmaceutically acceptable salt forms thereof, wherein: 
         the dashed line represents an optional double bond; 
         T is 
       
       
         
           
           
               
               
           
         
         R 1  is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R 1a ; 
         R 1a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , —S(O) 2 NR 9 C(O)R 6 , aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R 1b ; 
         R 1b , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 10 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 10 , —OH, —SH, —S(CR 8 R 8 ) r R 10 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 9 R 9 , —NR 9 R 9 , —S(O) 2 NR 9 R 9 , —NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 9 S(O) 2 R 6 , —S(O) 2 NR 9 C(═O)OR 6 , —S(O) 2 NR 9 C(═O)NR 9 R 9 , —C(═O)NR 9 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 10 , —NR 9 C(═O)H, —NR 9 C(═O)(CR 8 R 8 ) r R 10 , —OC(═O)(CR 8 R 8 ) r R 10 , —C(═NR 14 )NR 9 R 9 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 10 , —S(O) 2 (CR 8 R 8 ) r R 10 , —NR 9 C(═O)OR 8 , —NR 9 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 2  is alkyl, cycloalkyl, cycloalkylalkyl, or alkenyl, wherein the alkyl may be optionally substituted with —OH; 
         R 5  is halo, —CN or —Oalkyl; 
         R 6 , at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; 
         R 8 , at each occurrence, is independently hydrogen or alkyl; 
         R 9 , at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R 9a , and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 9a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 10 , at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R 10a , and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S; 
         R 10a , at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH 2 , —CN, —NO 2 , —C(═O)OH, —C(═O)O(CR 8 R 8 ) r R 14 , —O(CF 2 ) r CF 3 , —O(CR 8 R 8 ) r R 14 , —OH, —SH, —S(CR 8 R 8 ) r R 14 , —S(O) 3 H, —P(O) 3 H 2 , —C(═O)NR 14 R 14 , —NR 14 R 14 , —S(O) 2 NR 14 R 14 , —NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)NR 14 S(O) 2 R 6 , —S(O) 2 NR 14 C(═O)OR 6 , —S(O) 2 NR 14 C(═O)NR 14 R 14 , —C(═O)NR 14 S(O) 2 (CF 2 ) r CF 3 , —C(═O)(CR 8 R 8 ) r R 14 , —NR 14 C(═O)H, —NR 14 C(═O)(CR 8 R 8 ) r R 14 , —OC(═O)(CR 8 R 8 ) r R 14 , —C(═NR 14 )NR 14 R 14 , —NHC(═NR 14 )NR 14 R 14 , —S(═O)(CR 8 R 8 ) r R 14 , —S(O) 2 (CR 8 R 8 ) r R 14 , —NR 14 C(═O)OR 8 , —NR 14 S(O 2 )R 8 , aryloxy or arylalkyl; 
         R 14 , at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl; 
         m, at each occurrence, is 0-2; 
         n is 1-3; and 
         r is 0-5. 
       
     
     
         15 . A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of one or more compounds according to  claim 1 . 
     
     
         16 . A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of one or more compounds according to  claim 1 , wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerulonephritis, asthma, multiple sclerosis, arthrosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer. 
     
     
         17 . A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of one or more compounds according to  claim 7 . 
     
     
         18 . A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of one or more compounds according to  claim 7 , wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerulonephritis, asthma, multiple sclerosis, arthrosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer. 
     
     
         19 . A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of one or more compounds according to  claim 12 . 
     
     
         20 . A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of one or more compounds according to  claim 12 , wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerulonephritis, asthma, multiple sclerosis, arthrosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.

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