Cosmetic Composition Containing Acetylated Oligoglucuronans

Abstract

The present invention relates to the field of cosmetic and dermopharmaceutical compositions. It concerns oligomer compounds of D-glucuronic acid or D-glucuronate with a β (1-4) sequence (or oligoglucuronans) containing a degree of acetylation specifically between 8.7±0.5 and 9.2±0.5% by weight of O—CO—CH 3 group compared to the weight of glucuronic acid and with a degree of polymerisation (DP) of 18−19±2. The oligomer compounds according to the present invention are intended to stimulate the elasticity of the dermis and epidermis although they also act to increase derma-epidermal cohesion in order to combat skin ageing, lines, wrinkles, visible and/or tactile skin discontinuities, loss of firmness, elasticity and tone and to combat skin tissue deformability. The invention also concerns a cosmetic composition containing at least one compound as recited according to the present invention.

1 - 21 . (canceled) 
     
     
         22 . A composition comprising a mixture of compounds represented by formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 i) R individually represents a hydrogen atom or an acetyl group; 
 ii) n represents 15-16; and 
 iii) the mixture of compounds represented by formula (I) have a degree of acetylation of between 87% and 9.2% by weight of O—CO—CH 3  groups relative to the total weight of the compounds represented by formula (1) in the composition. 
 
       
     
     
         23 . The composition of  claim 22 , wherein the mixture of compounds of formula (I) are prepared by fermentation with a bacterium comprising a  Rhizobium meliloti  strain. 
     
     
         24 . A method of improving dermis and epidermis elasticity, comprising administering a composition including a mixture of compounds represented by formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 i) R individually represents a hydrogen atom or an acetyl group; and 
 ii) n represents 15-16. 
 
       
     
     
         25 . The method of  claim 24 , wherein the administered composition comprises the mixture of compounds of formula (I) in an amount of between 0.00001 wt. % and 50 wt. %, compared to the total weight of the composition. 
     
     
         26 . The method of  claim 24 , wherein the administered composition comprises the mixture of compounds of formula (I) in an amount of between 0.0001 wt. % and 30 wt. %, compared to the total weight of the composition. 
     
     
         27 . The method of  claim 24 , wherein the administered composition comprises the mixture of compounds of formula (I) in an amount of between 1 wt. % and 5 wt. %, compared to the total weight of the composition. 
     
     
         28 . The method of  claim 24 , wherein the administered composition:
 i) increases the elastic properties of the dermis and epidermis;   ii) promotes stimulation of hyaluronic acid synthesis; and/or   iii) promotes expression of CD44 receptors by keratinocytes.   
     
     
         29 . The method of  claim 28 , wherein the increased elasticity properties of the dermis and epidermis promotes elastin synthesis and/or preserves long lasting dermal proteins from glycation. 
     
     
         30 . The method of  claim 24 , wherein the administered composition:
 i) stimulates the elasticity of the dermis and epidermis;   ii) strengthens the dermo-epidermal cohesion; and/or   iii) reduces or minimizes skin ageing, lines, wrinkles, visible and/or tactile discontinuities of the skin, loss of firmness, elasticity or tone, and/or deformability of the skin tissue.   
     
     
         31 . The method of  claim 24 , wherein the administered composition:
 i) stabilises and strengthens the dermo-epidermal junction; and/or   ii) promotes stimulation of laminin 5 synthesis.   
     
     
         32 . The method of  claim 24 , wherein the administered composition moisturizes the skin; reduces or minimizes skin water loss; and/or decontracts, relaxes and/or smoothes the skin. 
     
     
         33 . The method of  claim 24 , wherein the administered composition is applied as a medicinal product. 
     
     
         34 . The method of  claim 33 , wherein the medicinal product treats wrinkles, treats lines, increases skin elasticity, and/or increases dermo-epidermal properties. 
     
     
         35 . The method of  claim 24 , wherein the administered composition the mixture of compounds of formula (I) in a physiologically acceptable medium. 
     
     
         36 . The method of  claim 24 , wherein the administered composition further comprises at least one additional active component, comprising:
 i) a moisturising agent;   ii) an anti-wrinkle agent;   iii) an anti-inflammatory agent;   iv) an anti-oxidising agent;   v) a sunscreen and/or filter-active substance; and   vi) a lightening agent.   
     
     
         37 . The method of  claim 24 , wherein the administered composition comprises the mixture of compounds of formula (I) in the form of: a solution; dispersion; emulsion; paste; or powder;
 wherein the oligomer compound of formula (I) is optionally carried individually or pre-mixed with carriers comprising: macrocapsules; microcapsules; nanocapsules; macrospheres; microspheres; nanospheres; liposomes; oleosomes; chylomicrons; macroparticles; microparticles; nanoparticles; macrosponges; microsponges; nanosponges; microemulsions; nanoemulsions; or adsorbed onto powderous organic polymers, talcs, bentonites, or other mineral or organic supports.   
     
     
         38 . The method of  claim 24 , wherein the administered composition comprises a galenic form, comprising: creams; lotions; unguents; milks; creams; gels; emulsions: dispersions; solutions; suspensions; cleansing agents; foundations; anhydrous preparations comprising sticks, lip balm, body oils, and bath oils: shower gels; bath gels; shampoos; hair-care products; make-up removing lotions or milks; lotions; sun-creams or milks; artificial tanning lotions, creams, or milks; shaving creams or foams; aftershave lotions; lipsticks; mascaras or nail varnish; skin essences; serum; adhesive or absorbent material; and/or transdermal patches or powders. 
     
     
         39 . The method of  claim 24 , wherein the mixture of compounds of formula (I) are prepared by fermentation with a bacterium comprising a  Rhizobium meliloti  strain. 
     
     
         40 . A method of promoting stimulation of hyaluronic acid synthesis, comprising administering a composition including a mixture of compounds represented by formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 i) R individually represents a hydrogen atom or an acetyl group; 
 ii) n represents 15-16: and 
 iii) the mixture of compounds represented by formula (I) have a degree of acetylation of between 8.7% and 9.2% by weight of O—CO—CH 3  groups relative to the total weight of the compounds represented by formula (I) in the composition. 
 
       
     
     
         41 . The method of  claim 40 , wherein the mixture of compounds of formula (I) are prepared by fermentation with a bacterium comprising a  Rhizobium meliloti  strain. 
     
     
         42 . A method of promoting expression of CD44 receptors by keratinocytes, comprising administering a composition including a mixture of compounds represented by formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 i) R individually represents a hydrogen atom or an acetyl group; 
 ii) represents 15-16; and 
 iii) the mixture of compounds represented by formula (I) have a degree of acetylation of between 8.7% and 9.2% by weight of O—CO—CH 3  groups relative to the total weight of the compounds represented by formula (I) in the composition.