Ab-remover, ab-removing apparatus, and ab removal method

Abstract

An object is to provide a material capable of removing Aβ from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid β protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.

1 . An amyloid β protein remover, comprising a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 22 carbon atoms on the surface thereof. 
     
     
         2 . The amyloid β protein remover according to  claim 1 , wherein the material is cellulose or activated carbon. 
     
     
         3 . The amyloid β protein remover according to  claim 1 , wherein the material is silica and the alkyl chain is bound to the carrier via a silanol group (SiOH). 
     
     
         4 . The amyloid β protein remover according to  claim 3 , wherein the number of carbon atoms is 1 to 5. 
     
     
         5 . The amyloid β protein remover according to  claim 3 , wherein the number of carbon atoms is 1 to 2. 
     
     
         6 . The amyloid β protein remover according to  claim 1 , wherein the material is silica and the carrier does not have an alkyl chain on the surface thereof. 
     
     
         7 . The amyloid β protein remover according to  claim 1 , wherein the material is activated carbon and the surface of the carrier is covered with a hydrophilic polymer. 
     
     
         8 . The amyloid β protein remover according to  claim 7 , wherein the hydrophilic polymer is a polymer of methacrylic acid 2-hydroxyethyl ester (pHEMA). 
     
     
         9 . An amyloid β protein removing apparatus, wherein the amyloid β protein remover according to  claim 1  is contained in a container provided with an inlet and an outlet. 
     
     
         10 . The amyloid β protein removing apparatus according to  claim 9 , wherein the container is in a shape of a column, and the amyloid β protein remover is filled in the container. 
     
     
         11 . An amyloid β protein removal system, comprising the amyloid β protein removing apparatus according to  claim 9 , and a pump for supplying a liquid to the amyloid β protein removing apparatus. 
     
     
         12 . The amyloid protein removal system according to  claim 11 , further comprising a dialysis apparatus serially connected to the amyloid β protein removing apparatus. 
     
     
         13 . The amyloid β protein remover according to  claim 1 , wherein the carrier is made of cellulose and has the alkyl chain on the surface thereof. 
     
     
         14 . The amyloid β protein remover according to  claim 13 , wherein the number of carbon atoms is 16 to 22. 
     
     
         15 . The amyloid β protein remover according to  claim 13 , wherein the number of carbon atoms is 16.