Composition and method for preventing/decreasing respiratory illness

Abstract

A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air. The adherence inhibiting material can be formulated for use in a variety of ways such as an oral spray or a nasal spray. These formulations can be effective to prevent or reduce respiratory illnesses in animals and humans.

1 . A composition for preventing or decreasing respiratory illness comprising adherence inhibiting material produced in eggs laid by female birds, wherein the birds are inoculated with one or more viruses or viral antigens causing the respiratory illness, the adherence inhibiting material formulated for dispersion into the respiratory tract for preventing or reducing or both the adherence of the virus causing the respiratory illness to the mucosal membranes of the respiratory tract. 
     
     
         2 . The composition of  claim 1  wherein the contents of the eggs, after separation from the shells, comprise the adherence inhibiting material, the egg contents formulated into the composition. 
     
     
         3 . The composition of  claim 1  wherein the adherence inhibiting material is an antibody. 
     
     
         4 . The composition of  claim 1  wherein the composition is formulated for a nasal spray. 
     
     
         5 . The composition of  claim 1  wherein the composition is formulated for an oral spray. 
     
     
         6 . The composition of  claim 1  wherein the composition further comprises a mucosal bio-adhesive. 
     
     
         7 . The composition of  claim 1  wherein the composition further comprises a pharmaceutical carrier. 
     
     
         8 . The composition of  claim 1  wherein the composition is formulated for dispersion into the nasopharynx of the respiratory tract. 
     
     
         9 . The composition of  claim 1  wherein the composition is formulated for placement onto an oral strip, wherein the adherence inhibiting material is released when the oral strip is placed in the mouth of the animal. 
     
     
         10 . An oral spray comprising the composition of  claim 1 . 
     
     
         11 . A nasal spray comprising the composition of  claim 1 . 
     
     
         12 . An oral strip comprising the composition of  claim 1 . 
     
     
         13 . A mouth rinse comprising the composition of  claim 1 . 
     
     
         14 . The composition of  claim 1  wherein the respiratory illness comprises influenza or other viral induced respiratory diseases. 
     
     
         15 . The composition of  claim 1  wherein the virus or viral antigens comprises H 1 N 1 , H 5 N 1 , H 3 N 2 , Infectious Bovine Rhinotracheitis, 1 and 5, BRSV and PI 3 , porcine respiratory and reproductive syndrome virus (PRRSv), Bovine adenovirus 1, 3, 5, 6, 7 and combinations thereof. 
     
     
         16 . The composition of  claim 1  wherein the respiratory illness is in humans. 
     
     
         17 . The composition of  claim 1  wherein the respiratory illness is in food animals. 
     
     
         18 . A method of preventing or reducing the incidence of respiratory illness caused by viruses in an animal, the method comprising:
 dispersing a composition comprising adherence inhibiting material produced in eggs laid by female birds, wherein the birds are inoculated with one or more viruses or virus antigens causing the respiratory illness, the composition formulated for dispersion into the respiratory tract to prevent or reduce the adherence of the virus causing the respiratory illness to the mucosal membranes of the respiratory tract.   
     
     
         19 . The method of  claim 18  wherein the composition is formulated as a nasal spray and the dispersing comprises spraying the contents of the nasal spray into the respiratory tract. 
     
     
         20 . The method of  claim 18  wherein the composition is formulated as an oral spray and the dispersing comprises spraying the contents of the oral spray into the mouth of the animal. 
     
     
         21 . The method of  claim 18  wherein the composition is placed onto an oral strip and the dispersing comprises placing the oral strip into the mouth of the animal. 
     
     
         22 . The method of  claim 18  wherein a mouth rinse comprises the composition and the dispersing is by gargling with the mouth rinse. 
     
     
         23 . The method of  claim 18  wherein the dispersing comprises coating the nasopharynx of the respiratory tract. 
     
     
         24 . The method of  claim 18  wherein the respiratory illness comprises influenza or other viral induced respiratory diseases. 
     
     
         25 . The method of  claim 18  wherein the virus or viral antigens comprises H 1 N 1 , H 5 N 1 , H 3 N 2 , Infectious Bovine Rhinotracheitis, 1 and 5, BRSV and PI 3 , porcine respiratory and reproductive syndrome virus (PRRSv), Bovine adenovirus 1, 3, 5, 6, 7 and combinations thereof. 
     
     
         26 . The method of  claim 18  wherein the respiratory illness is in humans. 
     
     
         27 . The method of  claim 18  wherein the respiratory illness is in food animals.