Compound with antimalarial activity and antimalarial drug containing the same as active ingredient

Abstract

Compounds with high antimalarial activity; and antimalarial drugs containing the same as an active ingredient. There are provided compounds with antimalarial activity represented by the chemical formula: (wherein R 1 is H, Cl or OCH 3 ; R 2 is H or CH 3 ; R 3 is CH, CH 2 , C(CH 3 ), CH(CH 3 ) or C(CH 3 ) 2 ; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan, thiophene or derivatives thereof; n is 1 to 5; and m is 1 to 5). Further, there are provided antimalarial drugs containing these compounds with antimalarial activity or pharmacologically acceptable salts thereof as active ingredients.

1 - 3 . (canceled) 
     
     
         4 . A compound with antimalarial activity represented by the following formula: 
       
         
           
           
               
               
           
         
       
       wherein R1 is H, Cl or OCH 3 ; R2 is H or CH 3 ; R3 is CH, CH 2 , C(CH 3 ), CH(CH 3 ) or C(CH 3 ) 2 ; Ar is imidazole, triazole, pyridine, benzene, pyrrole, furan or thiophene; n is 1 to 5; and m is 1 to 5. 
     
     
         5 . The compound with antimalarial activity according to  claim 4 , which is represented by a following chemical formula: 
       
         
           
           
               
               
           
         
       
       wherein R1 is H, Cl or OCH 3 ; R2 is H or CH 3 ; R3 is CH, CH 2 , C(CH 3 ), CH(CH 3 ) or C(CH 3 ) 2 ; R4 is H or CH 3 ; X is CH or N; n is 1 to 5; and m is 1 to 5. 
     
     
         6 . The compound with antimalarial activity according to  claim 5 , which is:
 (1) a compound represented by the chemical formula, wherein R1 is Cl; R2 is CH 3 ; R3 is CH 2 ; R4 is H; X is CH; n is 1; and m is 1; or   (2) a compound represented by the chemical formula, wherein R1 is Cl; R2 is CH 3 ; R3 is CH 2 ; R4 is H, X is CH; n is 2; and m is 2.   
     
     
         7 . An antimalarial drug comprising a compound with antimalarial activity according to  claim 4 , or pharmaceutically acceptable salts thereof as an active ingredient. 
     
     
         8 . An antimalarial drug comprising a compound with antimalarial activity according to  claim 5 , or pharmaceutically acceptable salts thereof as an active ingredient. 
     
     
         9 . An antimalarial drug comprising a compound with antimalarial activity according to  claim 6 , or pharmaceutically acceptable salts thereof as an active ingredient. 
     
     
         10 . A method of treating malaria, comprising administering an antimalarial drug according to  claim 7  to a subject. 
     
     
         11 . A method of treating malaria, comprising administering an antimalarial drug according to  claim 8  to a subject. 
     
     
         12 . A method of treating malaria, comprising administering an antimalarial drug according to  claim 9  to a subject.