Hepatitis C Virus Inhibitors

Abstract

This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

1 . A compound of Formula (I): 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein:
 A and B are independently selected from 
 
       
         
           
           
               
               
           
         
       
       provided that at least one of A and B is other than phenyl and provided that A-B is other than 
       
         
           
           
               
               
           
         
         Y is nitrogen (N) or CH; 
         Z is oxygen (O) or sulfur (S); 
         each R 24  is independently selected from hydrogen and halo; 
         R 1  is selected from 
       
       
         
           
           
               
               
           
         
       
       wherein p is 0 or 1;
 R 20  is selected from hydrogen and alkyl; 
 R 21  is selected from hydrogen and alkyl; 
 R 22  is hydrogen or —C(O)R x ; and 
 R 23  is selected from hydrogen and alkyl, wherein the alkyl can optionally form a fused three- to six-membered ring with an adjacent carbon atom, wherein the three- to six-membered ring is optionally substituted with one or two alkyl groups; 
 R 2  is hydrogen or —C(O)R y ; 
 R x  and R y  are each independently selected from cycloalkyl, heteroaryl, heterocyclyl, alkoxy, and alkyl, said alkyl being substituted by one or more substituents independently selected from aryl, alkenyl, cycloalkyl, heterocyclyl, heteroaryl, —OR 3 , —NR a R b , and —C(O)NR c R d , 
 wherein any said aryl and heteroaryl may optionally be substituted with one or more substituents independently selected from alkenyl, alkyl, haloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, cyano, nitro, —C(O)OR 4 , OR 5 , —NR a R b , (NR a R b )alkyl, and (MeO)(HO)P(O)O—, and 
 wherein any said cycloalkyl and heterocyclyl may optionally be fused onto an aromatic ring and may optionally be substituted with one or more substituents independently selected from alkoxy, alkyl, hydroxyl, halogen, aryl, —NR a R b , oxo, and —C(O)OR 4 ; 
 R 3  is hydrogen, alkyl, or arylalkyl; 
 R 4  is selected from alkyl and arylalkyl; 
 R 5  is hydrogen, alkyl, or arylalkyl; 
 R a  and R b  are independently selected from hydrogen, alkyl, cycloalkyl, arylalkyl, heteroaryl, —C(O)R 6 , —C(O)OR 7 , —C(O)NR c R d , and (NR c R d )alkyl, or alternatively, R a  and R b , together with the nitrogen atom to which they are attached, form a five- or six-membered ring or bridged bicyclic ring structure, wherein said five- or six-membered ring or bridged bicyclic ring structure optionally may contain one or two additional heteroatoms independently selected from nitrogen, oxygen, and sulfur and may contain one, two, or three substituents independently selected from C 1  to C 6  alkyl, C 1  to C 4  haloalkyl, aryl, hydroxyl, C 1  to C 6  alkoxy, C 1  to C 4  haloalkoxy, and halogen; 
 R 6  is alkyl; 
 R 7  is alkyl, cycloalkyl, arylalkyl, or haloalkyl; and 
 R c  and R d  are independently selected from hydrogen, alkyl, arylalkyl, and cycloalkyl. 
 
     
     
         2 . The compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, wherein Y is CH and Z is sulfur. 
     
     
         3 . The compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, wherein Y is nitrogen and Z is sulfur. 
     
     
         4 . The compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, wherein one of A and B is 
       
         
           
           
               
               
           
         
       
     
     
         5 . The compound according to  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
 R 1  is   
       
         
           
           
               
               
           
         
       
       wherein R 22  is —C(O)R x ;
 R 2  is —C(O)R y ; and 
 R x  and R y  are independently alkyl substituted by at least one —NR a R b , characterized by Formula (A): 
 
       
         
           
           
               
               
           
         
       
       wherein:
 m is 0 or 1; 
 R 8  is hydrogen or alkyl; 
 R 9  is selected from hydrogen, cycloalkyl, aryl, heteroaryl, heterocyclyl, and alkyl optionally substituted with a substituent selected from aryl, alkenyl, cycloalkyl, heterocyclyl, heteroaryl, heterobicyclyl, —OR 3 , —C(O)OR 4 , —NR a R b , and —C(O)NR c R d , 
 wherein aryl and heteroaryl may optionally be substituted with one or more substituents independently selected from alkenyl, alkyl, haloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, cyano, nitro, —C(O)OR 4 , OR 5 , —NR a R b , (NR a R b )alkyl, and (MeO)(HO)P(O)O—, and 
 wherein cycloalkyl and heterocyclyl may optionally be fused onto an aromatic ring and may optionally be substituted with one or more substituents independently selected from alkoxy, alkyl, hydroxyl, halogen, aryl, —NR a R b , oxo, and —C(O)OR 4 ; and 
 R 3 , R 4 , R 5 , R a , R b , R c , and R d  are defined as in  claim 1 . 
 
     
     
         6 . The compound of  claim 5 , or a pharmaceutically acceptable salt thereof, wherein:
 m is 0;   R 8  is hydrogen; and   R 9  is selected from hydrogen, cycloalkyl, aryl, and alkyl optionally substituted with one —OR 3  substituent.   
     
     
         7 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is   
       
         
           
           
               
               
           
         
         R 2  is —C(O)R y ; 
         R 20  is alkyl; 
         R 21  is hydrogen; 
         R 22  is —C(O)R x ; 
         R x  and R y  are independently alkyl substituted by at least one —NR a R b , characterized by Formula (A): 
       
       
         
           
           
               
               
           
         
       
       wherein:
 m is 0 or 1; 
 R 8  is hydrogen or alkyl; 
 R 9  is selected from hydrogen, cycloalkyl, aryl, heteroaryl, heterocyclyl, and alkyl optionally substituted with a substituent selected from aryl, alkenyl, cycloalkyl, heterocyclyl, heteroaryl, heterobicyclyl, —OR 3 , —C(O)OR 4 , —NR a R b , and —C(O)NR c R d , 
 wherein aryl and heteroaryl may optionally be substituted with one or more substituents independently selected from alkenyl, alkyl, haloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, halogen, cyano, nitro, —C(O)OR 4 , OR 5 , —NR a R b , (NR a R b )alkyl, and (MeO)(HO)P(O)O—, and 
 wherein cycloalkyl and heterocyclyl may optionally be fused onto an aromatic ring and may optionally be substituted with one or more substituents independently selected from alkoxy, alkyl, hydroxyl, halogen, aryl, —NR a R b , oxo, and —C(O)OR 4 ; and 
 R 3 , R 4 , R 5 , R a , R b , R c , and R d  are defined as in  claim 1 . 
 
     
     
         8 . The compound of  claim 7 , or a pharmaceutically acceptable salt thereof, wherein
 m is 0;   R 8  is hydrogen; and   R 9  is selected from hydrogen, cycloalkyl, aryl, and alkyl optionally substituted with one —OR 3  substituent.   
     
     
         9 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2  and R 22  are both hydrogen. 
     
     
         10 . A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
 (2S,2′S)-tert-Butyl 2,2′-(4,4′-(2,2′-bithiophene-5,5′-diyl)bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate;   5′-(2,2′-Bithiene-5,5′-diyl)bis(2-((2S)-2-pyrrolidinyl)-1H-imidazole);   Di-tert-butyl (2S,2′S)-2,2′-(5,5′-bi-1,3-thiazole-2,2′-diylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate);   2,2′-Bis(2-((2S)-2-pyrrolidinyl)-1H-imidazol-5-yl)-5,5′-bi-1,3-thiazole;   tert-Butyl (2S)-2-(4-(5′-(2-((2S)-1-(tert-butoxycarbonyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinecarboxylate; and   5,5′-Bis(2-((2S)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazole;   corresponding stereoisomers and tautomers thereof.   
     
     
         11 . A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
 Methyl ((1S)-2-((2S)-2-(4-(5′-(2-((2S)-1-(N-(methoxycarbonyl)-L-alanyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bithiophen-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate;   Methyl ((1S)-3-methoxy-1-(((2S)-2-(4-(5′-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-homoseryl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bithiophen-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Methyl ((1R)-1-(((2S)-2-(4-(5′-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bithiophen-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Dimethyl (2,2′-bithiene-5,5′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate; 1′R)-2,2′-(2,2′-Bithiene-5,5′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl))bis(N,N-dimethyl-2-oxo-1-phenylethanamine);   Methyl ((1S)-1-(((2S)-2-(4-(5′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bithiophen-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Dimethyl (2,2′-bithiene-5,5′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1S)-1-cyclopropyl-2-oxo-2,1-ethanediyl)))biscarbamate;   (1R,1′R)-2,2′-(5,5′-Bi-1,3-thiazole-2,2′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl))bis(N,N-dimethyl-2-oxo-1-phenylethanamine;   Dimethyl (5,5′-bi-1,3-thiazole-2,2′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate;   Methyl ((1S)-1-(((2S)-2-(4-(2′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-5,5′-bi-1,3-thiazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1R)-1-(((2S)-2-(4-(2′-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-5,5′-bi-1,3-thiazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1S,2R)-2-methoxy-1-(((2S)-2-(4-(2′-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-5,5′-bi-1,3-thiazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Methyl ((1S)-3-methoxy-1-(((2S)-2-(4-(2′-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-homoseryl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-5,5′-bi-1,3-thiazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Methyl ((1S)-1-(((2S)-2-(4-(5′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1S)-3-methoxy-1-(((2S)-2-(4-(5′-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-homoseryl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Dimethyl (2,2′-bi-1,3-thiazole-5,5′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate; 1′R)-2,2′-(2,2′-Bi-1,3-thiazole-5,5′-diylbis(1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl))bis(N,N-dimethyl-2-oxo-1-phenylethanamine);   Methyl ((1R)-1-(((2S)-2-(4-(5′-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1S,2R)-2-methoxy-1-(((2S)-2-(4-(5′-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Methyl ((1S)-2-((2S)-2-(4-(5′-(2-((2S)-1-(N-(methoxycarbonyl)-L-alanyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-2,2′-bi-1,3-thiazol-5-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate;   Methyl ((1R)-2-((2S)-2-(4-(3-(2-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-1,3-oxazol-5-yl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenylethyl)carbamate;   (1R)-2-((2S)-2-(4-(3-(2-(2-((2S)-1-((2R)-2-(Dimethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-1,3-oxazol-5-yl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-N,N-dimethyl-2-oxo-1-phenylethanamine;   Methyl ((1R)-2-((2S)-2-(4-(5-(3-(2-((1S)-1-(((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)amino)ethyl)-1H-imidazol-4-yl)phenyl)-1,3-oxazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenylethyl)carbamate;   (2R)-2-(Dimethylamino)-N-((1S)-1-(4-(3-(2-(2-((2S)-1-((2R)-2-(dimethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-1,3-oxazol-5-yl)phenyl)-1H-imidazol-2-yl)ethyl)-2-phenylacetamide;   Methyl ((1R)-2-((2S)-2-(4-(4-(2-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-1,3-oxazol-5-yl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenylethyl)carbamate;   (1R)-2-((2S)-2-(4-(4-(2-(2-((2S)-1-((2R)-2-(Dimethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)-1,3-oxazol-5-yl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-N,N-dimethyl-2-oxo-1-phenylethanamine;   Benzyl (2S)-2-(4-(5-(4-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)phenyl)-1,3-oxazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinecarboxylate;   Benzyl (2S)-2-(4-(5-(4-(2-((2S)-1-((2R)-2-((N,N-dimethyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)phenyl)-1,3-oxazol-2-yl)-1H-imidazol-2-yl)-1-pyrrolidinecarboxylate;   Dimethyl (1R,1′R)-2,2′-((2S,2′S)-2,2′-(5,5′-(buta-1,3-diyne-1,4-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl)dicarbamate;   (2R,2′R)-1,1′-((2S,2′S)-2,2′-(5,5′-(Buta-1,3-diyne-1,4-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(2-phenyl-2-(piperidin-1-yl)ethanone);   Dimethyl (2S,2′S)-1,1′-((2S,2′S)-2,2′-(5,5′-(buta-1,3-diyne-1,4-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate;   Dimethyl (2S,2′S)-1,1′-((2S,2′S)-2,2′-(5,5′-(buta-1,3-diyne-1,4-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(1-oxopropane-2,1-diyl)dicarbamate;   Methyl ((1S)-1-((2S)-2-(4-(4′-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1R)-2-((2S)-2-(4-(4-((2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenylethyl)carbamate;   Methyl ((1R)-2-((2S)-2-(4-(4-(2-(2-((2S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethyl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-2-oxo-1-phenylethyl)carbamate;   (1R)-2-((2S)-2-(4-(4-(2-(2-((2S)-1-((2R)-2-(Dimethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethyl)phenyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-N,N-dimethyl-2-oxo-1-phenylethanamine;   Methyl ((1S)-1-(((2S)-2-(4-((4-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)phenyl)ethynyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   Methyl ((1S,2R)-2-methoxy-1-(((2S)-2-(4-((4-((2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)phenyl)ethynyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Methyl ((1S)-2-((2S)-2-(4-((4-((2-((2S)-1-(N-(methoxycarbonyl)-L-alanyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)phenyl)ethynyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate;   Methyl ((1S)-3-methoxy-1-(((2S)-2-(4-((4-((2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-homoseryl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)phenyl)ethynyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   Dimethyl (1,3-butadiyne-1,4-diylbis(1H-imidazole-4,2-diyl(1R,3S,5R)-2-azabicyclo[3.1.0]hexane-3,2-diyl((1S)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)-2,1-ethanediyl)))biscarbamate;   (1R)-2-((2S)-2-(4-((E)-2-(4-((E)-2-(2-((2S)-1-((2R)-2-(diethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)vinyl)phenyl)vinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-N,N-diethyl-2-oxo-1-phenylethanamine;   dimethyl (1,4-phenylenebis((E)-2,1-ethenediyl-1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate;   methyl ((1S)-2-((2S)-2-(4-((E)-2-(4-((E)-2-(2-((2S)-1-(N-(methoxycarbonyl)-L-alanyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)vinyl)phenyl)vinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate;   methyl ((1S)-1-(((2S)-2-(4-((E)-2-(4-((E)-2-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)vinyl)phenyl)vinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate;   methyl ((1S,2R)-2-methoxy-1-(((2S)-2-(4-((E)-2-(4-((E)-2-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)vinyl)phenyl)vinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   (1R)-2-((2S)-2-(4-(2-(4-(2-(2-((2S)-1-(2R)-2-(diethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)ethyl)phenyl)ethyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-N,N-diethyl-2-oxo-1-phenylethanamine;   dimethyl (1,4-phenylenebis(2,1-ethanediyl-1H-imidazole-4,2-diyl(2S)-2,1-pyrrolidinediyl((1R)-2-oxo-1-phenyl-2,1-ethanediyl)))biscarbamate;   methyl ((1S)-2-((2S)-2-(4-(2-(4-(2-(2-((2S)-1-(N-(methoxycarbonyl)-L-alanyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethyl)phenyl)ethyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate;   methyl ((1S)-1-(2S)-2-(4-(2-(4-(2-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethyl)phenyl)ethyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate; and   methyl ((1S,2R)-2-methoxy-1-(((2S)-2-(4-(2-(4-(2-(2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethyl)phenyl)ethyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)propyl)carbamate;   and corresponding stereoisomers and tautomers thereof.   
     
     
         12 . A composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
         13 . A method of treating an HCV infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound of  claim 1 , or a pharmaceutically acceptable salt thereof.