Use of thymus capitatus extract, satureja hortensis extract, or carvacrol for treating metabolic diseases

Abstract

Disclosed is an use of Spanish oregano ( Thymus capitatus ) extract, summer savory ( Satureja hortensis ) extract or carvacrol for treating metabolic diseases. More specifically, the present disclosure relates to a composition containing Spanish oregano extract or summer savory extract, carvacrol, which is an aromatic oil component frequently found in mint, oregano, thyme, bergamot camphor tree or thyme thymol, as an active ingredient, for preventing and treating a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes, an use thereof, and a method of using the same. The disclosed composition, use and method are useful for weight loss, suppression of abdominal fat accumulation, treatment of fatty liver, reduction of cholesterol and free fatty acid in plasma and liver tissue, and improvement of blood glucose level and insulin resistance. Therefore, the composition can be effectively used to prevent and treat a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes.

1 . A pharmaceutical composition for preventing and treating fatty liver or diabetes (a metabolic disease selected from the group consisting of fatty liver, hyperlipidemia and diabetes) comprising carvacrol represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient: 
       
         
           
           
               
               
           
         
       
     
     
         2 . A use of carvacrol represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof for preparing an agent for preventing and treating fatty liver or diabetes (a metabolic disease selected from the group consisting of fatty liver, hyperlipidemia and diabetes). 
     
     
         3 . A method for preventing and treating fatty liver or diabetes (a metabolic disease selected from the group consisting of fatty liver, hyperlipidemia and diabetes) comprising administering an effective amount of carvacrol represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof.l 
     
     
         4 . A food composition for preventing and treating fatty liver or diabetes (a metabolic disease selected from the group consisting of fatty liver, hyperlipidemia and diabetes) comprising carvacrol represented by Chemical Formula 1 or a salt thereof as an active ingredient. 
     
     
         5 . A pharmaceutical composition for preventing and treating a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes, comprising Spanish oregano ( Thymus capitatus ) extract or summer savory ( Satureja hortensis ) extract as an active ingredient. 
     
     
         6 . The composition according to  claim 5 , wherein the Spanish oregano extract or summer savory extract is prepared using water, a C 1 -C 6  alcohol or a mixture solvent thereof. 
     
     
         7 . An use of Spanish oregano ( Thymus capitatus ) extract or summer savory ( Satureja hortensis ) extract for preparing an agent for preventing and treating a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes. 
     
     
         8 . The use according to  claim 7 , wherein the Spanish oregano extract or summer savory extract is prepared using water, a C 1 -C 6  alcohol or a mixture solvent thereof. 
     
     
         9 . A method for preventing and treating a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes, comprising administering an effective amount of Spanish oregano ( Thymus capitatus ) extract or summer savory ( Satureja hortensis ) extract to a subject in need thereof. 
     
     
         10 . The method according to  claim 9 , wherein the Spanish oregano extract or summer savory extract is extracted using water, a C 1 -C 6  alcohol or a mixture solvent thereof. 
     
     
         11 . A food composition for preventing and treating a metabolic disease selected from the group consisting of obesity, fatty liver, hyperlipidemia and diabetes, comprising Spanish oregano ( Thymus capitatus ) extract or summer savory ( Satureja hortensis ) extract as an active ingredient.