Medical product for treating stenosis of body passages and for preventing threatening restenosis

Abstract

A method for coating catheter balloons with a defined amount of a pharmacologically active agent, uses a coating device having a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device specifically onto the surface of the catheter balloon.

1 - 47 . (canceled) 
     
     
         48 . A method for coating a catheter balloon with a defined amount of a pharmacologically active agent, comprising applying a coating solution to the surface of the catheter balloon, wherein the coating device comprises a volume measuring device for releasing a measurable amount of a coating solution by means of a dispensing device to the surface of the catheter balloon and wherein the dispensing device is a thread, a mesh of threads, a piece of textile, a leather strip, a sponge, a syringe, a needle or a cannula. 
     
     
         49 . The method according to  claim 48 , wherein the coating is applied by a drag method or a thread drag method. 
     
     
         50 . The method according to  claim 48 , wherein the coating solution contains a pharmacologically active agent together with at least one transport mediator, citrate ester, contrast medium, polymer, polysaccharide, peptide, nucleotide, oil, fat, wax, fatty acid, fatty acid ester, hydrogel, salt, solvent, pharmacologically acceptable excipient or a mixture of the aforementioned substances. 
     
     
         51 . The method according to  claim 48 , wherein applying the coating solution to the surface of the catheter balloon comprises:
 a) providing a catheter balloon in a folded, partially inflated or completely inflated state,   b) providing a coating device with a dispensing device,   c) forming of a drop of the coating solution at the dispensing device,   d) dragging the drop over the surface of the catheter balloon to be coated without the dispensing device itself contacting the surface of the catheter balloon, and   e) redosing of the coating solution so that the drop substantially maintains its size.   
     
     
         52 . The method according to  claim 51 , wherein specifically only the folds of the catheter balloon are filled by dragging the drop over the opening of the fold. 
     
     
         53 . The method according to  claim 51 , wherein the surface of the catheter balloon is bedewed before coating with a solvent. 
     
     
         54 . The method according to  claim 48 , wherein applying the coating solution to the surface of the catheter balloon comprises:
 a) providing a catheter balloon in a folded, partially inflated or completely inflated state,   b) providing a coating device with a dispensing device in form of a thread, sponge, leather strip or piece of textile,   c) providing a coating solution,   d) soaking the dispensing device with the coating solution,   e) transferring the coating solution from the dispensing device onto the surface of the catheter balloon to be coated, and   f) redosing of the coating solution so that a consistent dispense of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated occurs.   
     
     
         55 . The method according to  claim 54 , wherein the transfer of the coating solution from the dispensing device onto the surface of the catheter balloon to be coated is effected by dragging the dispensing device over the surface of the catheter balloon to be coated. 
     
     
         56 . The method according to  claim 54 , wherein specifically only the folds of the catheter balloon are filled by dragging the dispensing device over the opening of the fold or through the folds. 
     
     
         57 . The method according to  claim 54 , wherein the surface of the catheter balloon is bedewed before coating with a solvent. 
     
     
         58 . The method according to  claim 54 , wherein the dispensing device comprises a material that doesn't damage the catheter balloon. 
     
     
         59 . The method according to  claim 48 , wherein all folds of the catheter balloon are coated or filled concomitantly. 
     
     
         60 . The method according to  claim 48 , wherein the complete surface of the catheter balloon is coated concomitantly by a plurality of threads, leather strips, a piece of textile or a mesh of threads.