Novel bag proteins and nucleic acid molecules encoding them

Abstract

The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S. pombe (BAG-1A, BAG-1B) and the nucleic acid molecules that encode them.

1 . A substantially purified nucleic acid molecule having a nucleotide sequence corresponding to or complementary to at least 20 nucleotides from a nucleotide sequence selected from the group consisting of (SEQ ID NO:1), (SEQ ID NO:3), (SEQ ID NO:5), (SEQ ID NO:7), (SEQ ID NO:9), (SEQ ID NO:19), (SEQ ID NO:21) and (SEQ ID NO:23). 
     
     
         2 . The nucleic acid of  claim 1  having a nucleotide sequence corresponding to or complementary to a nucleotide sequence that encodes a functionally active BAG family protein selected from the group consisting of (SEQ ID NO:2), (SEQ ID NO:4), (SEQ ID NO:6), (SEQ ID NO:8), (SEQ ID NO:10), (SEQ ID NO:20), (SEQ ID NO:22) and (SEQ ID NO:24). 
     
     
         3 . The nucleic acid of  claim 2  selected from the group consisting of (SEQ ID NO:1), (SEQ ID NO:3), (SEQ ID NO:5), (SEQ ID NO:7), (SEQ ID NO:9), (SEQ ID NO:19), (SEQ ID NO:21) and (SEQ ID NO:23). 
     
     
         4 . The nucleic acid of  claim 2  complementary to a nucleotide sequence that encodes a functionally active BAG protein selected from the group consisting of (SEQ ID NO:2), (SEQ ID NO:4), (SEQ ID NO:6), (SEQ ID NO:8), (SEQ ID NO:10), (SEQ ID NO:20), (SEQ ID NO:22) and (SEQ ID NO:24). 
     
     
         5 . The substantially purified nucleic acid molecule of  claim 1  having a nucleotide sequence selected from the group consisting of (SEQ ID NO:3), (SEQ ID NO:5), (SEQ ID NO:7), (SEQ ID NO:9), (SEQ ID NO:19), (SEQ ID NO:21) and (SEQ ID NO:23). 
     
     
         6 . A substantially purified BAG family protein encoded by the nucleic acid molecule of  claim 1 . 
     
     
         7 . A substantially purified BAG family protein comprising the amino acid sequence selected from the group consisting of (SEQ ID NO:2), (SEQ ID NO:4), (SEQ ID NO:6), (SEQ ID NO:8), (SEQ ID NO:10), (SEQ ID NO:20), (SEQ ID NO:22) and (SEQ ID NO:24) or a fragment, a derivative or a mimetic thereof. 
     
     
         8 . A substantially purified protein corresponding to the amino acid sequence selected from the group consisting of the amino acid sequence of 157 to 204 of (SEQ ID NO:2), 272 to 319 of (SEQ ID NO:2), 164 to 211 of (SEQ ID NO:4), 418 to 510 of (SEQ ID NO:20), 378 to 457 of (SEQ ID NO:22), 6 to 97 of (SEQ ID NO:24), 180 to 257 of (SEQ ID NO:24), 272 to 349 of (SEQ ID NO:24), and 362 to 444 of (SEQ ID NO:24). 
     
     
         9 . A pharmaceutical composition comprising a nucleic acid molecule of  claim 1 . 
     
     
         10 . A pharmaceutical composition comprising the substantially purified BAG family protein of  claim 7 .