Method of treating coronary arteries with perivascular delivery of therapeutic agents

Abstract

A method of treating the intraluminal disease in a coronary artery by injecting therapeutic agents perivascularly into the myocardium near the site of disease.

1 . A method of preventing restenosis in a artery by delivering a therapeutic amount of antirestenotic agents selected from the set of antiproliferative agents which inhibit smooth muscle proliferation, endothelial proliferation, endothelial cell proliferation, and growth of other components of arterial plaque and stenosis locally to the coronary arteries via controlled release biodegradable polymers. 
     
     
         2 . The method of  claim 1  in which said polymers are implanted periadventicially proximate the artery. 
     
     
         3 . The method of  claim 1  in which the vessel is a coronary artery. 
     
     
         4 . The method of  claim 3  in which the agents are delivered intramyocardially and migrate to a periadventicial location. 
     
     
         5 . A method of preventing restenosis in a artery by delivering a therapeutic amount of agent selected from the set of statin agents, anti-inflammatory agents, antioxidant agents, Pemirolast, Tranilast, cilostrazol, INOS, ENOS, and ECNOS, locally to the coronary arteries via controlled release biodegradable polymers. 
     
     
         6 . The method of  claim 5  in which said polymers are implanted periadventicially proximate the artery. 
     
     
         7 . The method of  claim 5  in which the vessel is a coronary artery. 
     
     
         8 . The method of  claim 7  in which the agents are delivered intramyocardially and migrate to a periadventicial location.