US2011293640A1PendingUtilityA1

Cholinesterase Inhibitors for Treating Inflammation

Individually held — no corporate assignee on recordPriority: Jan 27, 2004Filed: May 27, 2011Published: Dec 1, 2011
Est. expiryJan 27, 2024(expired)· nominal 20-yr term from priority
A61P 37/06A61P 31/00A61P 29/00A61K 31/439A61P 1/18A61K 31/473A61K 31/407A61P 1/02A61K 31/4747A61K 31/325A61K 31/55A61P 11/06A61K 31/50A61K 31/00
48
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Claims

Claims

exact text as granted — not AI-modified
1 . A method of treating a subject with a cytokine-mediated inflammatory disorder, comprising:
 administering to the subject a pharmaceutically acceptable cholinesterase inhibitor in an amount sufficient to reduce the level of a proinflammatory cytokine, provided that the inhibitor is not galantamine, wherein the inflammatory disorder is asthma.   
     
     
         2 - 15 . (canceled) 
     
     
         16 . The method of  claim 1 , wherein the cholinesterase inhibitor is at least one selected from the group consisting of tacrine, a tacrine analog, fasciculin, metrifonate, heptyl-physostigmine, norpyridostigmine, nomeostigmine, huperzine A or an analogue thereof, physostigmine, heptylphysostigmine, velnacrine, citicoline, donepezil, 7-methoxytacrine, eptastigmine, icopezil, ipidacrine, zifrosilone, anseculin, suronacrine, linopiridine, rivastigmine, neostigmine, edrophonium, deinacarium, ambenonium, arecoline, xanomeline, subcomeline, cevimeline, alvameline, milameline, talsaclidine, and compounds of formulae (XVIII)-(XXI): 
       
         
           
           
               
               
           
         
       
     
     
         17 . (canceled) 
     
     
         18 . The method of  claim 1  wherein the cholinesterase inhibitor is at least 95% pure by weight. 
     
     
         19 . The method of  claim 16  wherein the cholinesterase inhibitor is tacrine. 
     
     
         20 . The method of  claim 16  wherein the cholinesterase inhibitor is huperzine A. 
     
     
         21 . The method of  claim 16  wherein the cholinesterase inhibitor is neostigmine. 
     
     
         22 . The method of  claim 16  wherein the cholinesterase inhibitor is physostigmine. 
     
     
         23 . A method of reducing proinflammatory cytokine levels in a subject in need of such reduction, comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor, provided that the inhibitor is not galantamine, wherein the subject suffers from asthma. 
     
     
         24 . A method of treating a subject suffering from a disorder, comprising:
 administering to the subject a therapeutically effective amount of pharmaceutically acceptable cholinesterase inhibitor, wherein the disorder is asthma, provided that the inhibitor is not galantamine.

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