Methods for breast cancer risk assessment

Abstract

The present invention relates to methods and systems for assessing the overall risk of a human female subject for developing a breast cancer phenotype. In particular, the present invention relates to combining clinical risk assessment and genetic risk assessment to improve risk analysis.

1 - 38 . (canceled) 
     
     
         39 . A method for assessing the overall risk of a human female subject for developing a cancer phenotype comprising:
 performing a clinical risk assessment of the female subject using the Gail Model;   performing a genetic risk assessment of the female subject, wherein the genetic risk assessment involves detecting, in a biological sample derived from the female subject, for the presence of at least the following single nucleotide polymorphisms known to be associated with a cancer phenotype, rs2981582, rs3803662, rs889312, rs13387042, rs13281615, rs4415084, and rs3817198; and   multiplying the clinical risk assessment with the genetic risk assessment to obtain the overall risk of a human female subject for developing a cancer phenotype.   
     
     
         40 . The method of  claim 39 , wherein the single nucleotide polymorphisms are rs2981582, rs3803662, rs889312, rs13387042, rs13281615, rs4415084, rs3817198, rs4973768, rs6504950 and rs11249433. 
     
     
         41 . The method of  claim 39 , wherein the single nucleotide polymorphisms are individually tested for association with cancer by logistic regression under a log additive model with no covariates.