Treatment of Development-Related Disorders

Abstract

Disclosed are composition and methods for treating development-related disorders. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods.

1 - 15 . (canceled) 
     
     
         16 . A method of assessing a subject's cancer prognosis, the method comprising:
 obtaining a biological sample from the subject, and   determining the presence of a gene encoding a polypeptide containing SEQ ID NO: 1 in the biological sample,   wherein the subject is determined to have a good prognosis if the gene is present on both chromosomes or to have a poor prognosis if the gene is missing from one of the chromosomes.   
     
     
         17 . The method of  claim 16 , wherein the biological sample is a tumor biopsy sample, a blood sample, a urine sample, or a stool sample. 
     
     
         18 . A method of assessing a subject's cancer prognosis, the method comprising:
 obtaining a biological sample from the subject; and   determining the expression level of a gene encoding a polypeptide containing SEQ ID NO: 1 in the biological sample,   
       wherein the subject is determined to have a good prognosis if the expression level increases after a cancer treatment or to have a poor prognosis if the expression level fails to increase after the cancer treatment. 
     
     
         19 . The method of  claim 18 , wherein the method further comprises contacting the biological sample with a chemotherapeutical agent prior to determining the express level of a gene encoding a polypeptide containing SEQ ID NO: 1 in the sample. 
     
     
         20 . The method of  claim 18 , wherein the biological sample is a tumor biopsy sample, a blood sample, a urine sample, or a stool sample. 
     
     
         21 - 31 . (canceled) 
     
     
         32 . The method of  claim 17 , wherein the biological sample is a blood sample. 
     
     
         33 . The method of  claim 17 , wherein the biological sample is a tumor biopsy sample. 
     
     
         34 . The method of  claim 17 , wherein the biological sample is a urine sample. 
     
     
         35 . The method of  claim 19 , wherein the biological sample is a tumor biopsy sample, a blood sample, a urine sample, or a stool sample. 
     
     
         36 . The method of  claim 35 , wherein the biological sample is a blood sample. 
     
     
         37 . The method of  claim 35 , wherein the biological sample is a tumor biopsy sample. 
     
     
         38 . The method of  claim 35 , wherein the biological sample is a urine sample. 
     
     
         39 . The method of  claim 20 , wherein the biological sample is a blood sample. 
     
     
         40 . The method of  claim 20 , wherein the biological sample is a tumor biopsy sample. 
     
     
         41 . The method of  claim 20 , wherein the biological sample is a urine sample. 
     
     
         42 . A method of diagnosing cancer, the method comprising:
 obtaining a biological sample from the subject, and   determining the expression level of a gene encoding a polypeptide containing   SEQ ID NO: 1 in the biological sample,   
       wherein the subject is determined to have cancer if the expression level is lower than that in a cancer-free control. 
     
     
         43 . The method of  claim 42 , wherein the biological sample is a tumor biopsy sample, a blood sample, a urine sample, or a stool sample. 
     
     
         44 . The method of  claim 43 , wherein the biological sample is a blood sample. 
     
     
         45 . The method of  claim 43 , wherein the biological sample is a tumor biopsy sample. 
     
     
         46 . The method of  claim 43 , wherein the biological sample is a urine sample.