Prodrugs of ion channel modulating compounds and uses thereof

Abstract

Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs.

1 .- 25 . (canceled) 
     
     
         26 . A compound having the following formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         27 . A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a therapeutically effective amount of a compound having the following formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         28 . A method of treating or preventing arrhythmia in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a compound of  claim 26 , or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of  claim 27 . 
     
     
         29 . A method for modulating ion channel activity in a subject, wherein the method comprises administering to the subject a therapeutically effective amount of a compound of  claim 26 , or a pharmaceutically acceptable salt thereof, or a therapeutically effective amount of a pharmaceutical composition of  claim 27 . 
     
     
         30 . A method of preparing a compound having the following formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein the method comprises treating a compound of formula (PRO-A-Za1): 
       
         
           
           
               
               
           
         
       
       under standard enzymatic conditions, to provide the compound having the following formula: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof.