Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis

Abstract

The present invention provides formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D 3 . The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.

1 . A composition comprising at least 11 percent by weight of calcium in the form of calcium acetate, at least 5 percent by weight of magnesium in the form of magnesium acetate, and at least 0.5 percent by weight of zinc in the form of zinc acetate, wherein said composition comprises more bioavailable calcium per unit weight than calcium carbonate or calcium citrate. 
     
     
         2 . The composition of  claim 1 , further comprising at least 400 IU of vitamin D 3 . 
     
     
         3 . The composition of  claim 1 , wherein the composition comprises a daily dose of 5-40 mg of zinc, or a daily dose of 400 to 3000 IU of vitamin D 3 . 
     
     
         4 . The composition of  claim 1 , wherein the composition comprises a daily dose of 50 to 500 mg of calcium and 25 to 500 mg of magnesium. 
     
     
         5 . The composition of  claim 1 , wherein the composition comprises a daily dose of 100 to 300 mg of calcium and 50 to 150 mg of magnesium. 
     
     
         6 . The composition of  claim 1  wherein the composition comprises 400 to 1200 IU of vitamin D 3  per 220 mg of calcium. 
     
     
         7 . A fruit juice composition comprising the composition of  claim 1 . 
     
     
         8 . The fruit juice of  claim 7 , wherein the fruit juice is orange juice, grape juice or carrot juice. 
     
     
         9 . A method for alleviating or treating symptoms of osteoporosis, or for increasing bone mineral density in humans or animals, comprising the step of administering the composition of  claim 1  to said humans or animals. 
     
     
         10 . A composition comprising at least 7 percent by weight of calcium in the form of calcium acetate, at least 7 percent by weight of magnesium in the form of magnesium acetate, and at least 0.3 percent by weight of zinc in the form of zinc acetate, wherein said composition comprises more bioavailable calcium per unit weight than calcium carbonate or calcium citrate. 
     
     
         11 . The composition of  claim 10 , further comprising at least 400 IU of vitamin D 3 . 
     
     
         12 . The composition of  claim 10 , wherein the composition comprises a daily dose of 5-40 mg of zinc, or a daily dose of 400 to 1200 IU of vitamin D 3 . 
     
     
         13 . The composition of  claim 10 , wherein the composition comprises a daily dose of 50 to 500 mg of calcium and 25 to 500 mg of magnesium. 
     
     
         14 . The composition of  claim 10 , wherein the composition comprises a daily dose of 100 to 300 mg of calcium and 50 to 150 mg of magnesium. 
     
     
         15 . The composition of  claim 10 , wherein the composition comprises 400 to 1200 IU of vitamin D 3  per 200 mg of calcium. 
     
     
         16 . A fruit juice composition comprising the composition of  claim 10 . 
     
     
         17 . The fruit juice of  claim 16 , wherein the fruit juice is orange juice, grape juice or carrot juice. 
     
     
         18 . A method for alleviating or treating symptoms of osteoporosis, or for increasing bone mineral density in humans or animals, comprising the step of administering the composition of  claim 10  to said humans or animals. 
     
     
         19 . A method of preparing tablets comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D 3 , comprising the steps of:
 (i) blending a calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate with a composition comprising vitamin D 3 ; and   (ii) blending the composition obtained from (i) with a calcium composition comprising calcium acetate, magnesium acetate, and zinc acetate, thereby obtaining tablets comprising calcium acetate, magnesium acetate, zinc acetate and vitamin D 3 .   
     
     
         20 . The method of  claim 19 , wherein the calcium composition comprises at least 14 percent by weight of calcium acetate, at least 7 percent by weight of magnesium acetate, and at least 0.7 percent by weight of zinc acetate. 
     
     
         21 . A tablet produced by the method of  claim 19 .