Pharmaceutical composition for treating or releiving inflammatory bowel disease

Abstract

A pharmaceutical composition for treating or relieving inflammatory bowel disease (IBD) is provided. The pharmaceutical composition includes an extract of Bupleurum as an active ingredient, in which the Bupleurum is selected from the group consisting of Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi and a combination thereof.

1 . A pharmaceutical composition for treating or relieving inflammatory bowel disease, comprising an extract of  Bupleurum  as an active ingredient. 
     
     
         2 . The pharmaceutical composition as claimed in  claim 1 , wherein the  Bupleurum  is selected from a species which is slightly cold in nature and bitter to the taste. 
     
     
         3 . The pharmaceutical composition as claimed in  claim 1 , wherein the  Bupleurum  is selected from the group consisting of  Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi  and a combination thereof. 
     
     
         4 . The pharmaceutical composition as claimed in  claim 1 , wherein the extract of  Bupleurum  is extracted from the root thereof. 
     
     
         5 . The pharmaceutical composition as claimed in  claim 1 , wherein the  Bupleurum  is extracted with an ethanol aqueous solution in a concentration of about 20˜95% by volume. 
     
     
         6 . The pharmaceutical composition as claimed in  claim 5 , wherein the ethanol aqueous solution is in a concentration of about 40˜95% by volume. 
     
     
         7 . The pharmaceutical composition as claimed in  claim 1 , wherein the inflammatory bowel disease comprises Crohn's disease, enteritis or a bowel disease with an inflammatory symptom. 
     
     
         8 . A method for treating or relieving inflammatory bowel disease, comprising administrating an extract of  Bupleurum  to a subject. 
     
     
         9 . The method as claimed in  claim 8 , wherein the  Bupleurum is  selected from a species which is slightly cold in nature and bitter to the taste 
     
     
         10 . The method as claimed in  claim 8 , wherein the  Bupleurum  is selected from the group consisting of  Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi  and a combination thereof. 
     
     
         11 . The method as claimed in  claim 8 , wherein the extract of  Bupleurum  is extracted from the root thereof. 
     
     
         12 . The method as claimed in  claim 8 , wherein the  Bupleurum  is extracted with an ethanol aqueous solution in a concentration of about 20˜95% by volume. 
     
     
         13 . The method as claimed in  claim 12 , wherein the ethanol aqueous solution is in a concentration of about 40˜95% by volume. 
     
     
         14 . The method as claimed in  claim 8 , wherein the inflammatory bowel disease comprises Crohn's disease, enteritis or a bowel disease with an inflammatory symptom. 
     
     
         15 . The method as claimed in  claim 8 , wherein the extract of  Bupleurum  is orally administrated. 
     
     
         16 . The method as claimed in  claim 8 , wherein the subject comprises a human. 
     
     
         17 . A method for preparing a medicament of treating or relieving inflammatory bowel disease, comprising:
 providing an extract of  Bupleurum  as an active ingredient, in preparation of a medicament of treating or relieving inflammatory bowel disease.   
     
     
         18 . The method as claimed in  claim 17 , wherein the  Bupleurum  is selected from a species which is slightly cold in nature and bitter to the taste. 
     
     
         19 . The method as claimed in  claim 17 , wherein the Bupleurum is selected from the group consisting of  Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi  and a combination thereof. 
     
     
         20 . The method as claimed in  claim 17 , wherein the extract of  Bupleurum  is extracted from the root thereof. 
     
     
         21 . The method as claimed in  claim 17 , wherein the  Bupleurum  is extracted with an ethanol aqueous solution in a concentration of about 20˜95% by volume.