Use of inhibitors of jun n-terminal kinases to treat glaucoma

Abstract

Compositions and methods for lowering IOP and/or providing neuroprotection are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK) to lower IOP and/or provide neuroprotection.

1 . A method for providing neuroprotection in an eye of a human patient identified as having glaucoma, said method comprising administering to the human patient a composition comprising a therapeutically effective amount of 2H-Dibenzo[cd,g]indazol-6-one (SP600125). 
     
     
         2 . A method according to  claim 1 , wherein the composition is an oral formulation. 
     
     
         3 . A method according to  claim 1 , wherein the composition is a topical ophthalmic, surgical irrigating solution or an intraocular formulation.