Natriuretic activities

Abstract

This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.

1 . A method for inducing a natriuretic or diuretic action in a mammal, said method comprising administering to said mammal a polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:1, or an amino acid sequence as set forth in SEQ ID NO:1 having less than five amino acid additions, subtractions, and substitutions. 
     
     
         2 . The method of  claim 1 , wherein said polypeptide comprises an amino acid sequence present in an ANP polypeptide. 
     
     
         3 . The method of  claim 1 , wherein said polypeptide comprises an amino acid sequence present in a BNP polypeptide. 
     
     
         4 . The method of  claim 1 , wherein said polypeptide comprises an amino acid sequence present in a CNP polypeptide. 
     
     
         5 . The method of  claim 1 , wherein said polypeptide comprises an amino acid sequence present in a DNP polypeptide. 
     
     
         6 . The method of  claim 1 , wherein said polypeptide comprises an amino acid sequence present in a salmon natriuretic factor polypeptide. 
     
     
         7 . The method of  claim 1 , wherein said polypeptide comprises the amino acid sequence as set forth in SEQ ID NO:1. 
     
     
         8 . The method of  claim 1 , wherein said polypeptide comprises the amino acid sequence as set forth in SEQ ID NO:1 having less than five amino acid additions, subtractions, and substitutions. 
     
     
         9 . The method of  claim 1 , wherein said polypeptide comprises the amino acid sequence as set forth in SEQ ID NO:1 having less than four amino acid additions, subtractions, and substitutions.