Hypoxia-Inducible Protein 2 (HIG2), a Diagnostic Marker for Clear Cell Renal Cell Carcinoma

Abstract

The present invention provides a method for inhibiting growth of a cancer cell, particularly a renal cell carcinoma, by contacting the cell with a composition composed of an HIG2 siRNA or HIG2 antibody. Methods of diagnosing renal cell cancer are also provided within the present invention.

1 - 17 . (canceled) 
     
     
         18 . A method of screening for a compound for treating or preventing RCC, said method comprising the steps of:
 a) contacting a test compound with a polypeptide encoded by HIG 2;   b) detecting the biological activity of the polypeptide of step (a); and   c) selecting the test compound that suppresses the biological activity of the polypeptide encoded by HIG 2 in comparison with the biological activity detected in the absence of the test compound.   
     
     
         19 . The method of  claim 18 , wherein the biological activity of the polypeptide is cell proliferation activity. 
     
     
         20 . (canceled) 
     
     
         21 - 46 . (canceled)