Novel Coated Membranes and Other Articles

Abstract

The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.

1 - 60 . (canceled) 
     
     
         61 . A method for removing cells from a solution comprising the steps of: providing a solution comprising having undesired cells; and filtering said solution through a clean, caustic resistant, porous membrane comprising a polyvinylidene difluoride microporous membrane substrate and a heat stable biomolecule resistant surface, wherein said heat stable biomolecule resistant surface is a separately formed surface coating which comprises a crosslinked terpolymer, said crosslinked terpolymer being a copolymer formed from either: (a) methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide; or (b) methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide. 
     
     
         62 . A method for sterilizing a solution comprising the steps of: providing a nonsterile solution; and filtering said solution through a clean, caustic resistant, porous membrane comprising a polyvinylidene difluoride microporous membrane substrate and a heat stable biomolecule resistant surface wherein said heat stable biomolecule resistant surface is a separately formed surface coating which comprises a crosslinked terpolymer, said crosslinked terpolymer being a copolymer formed from either: (a) methylene-bis-acrylamide, dimethylacrylamide, and diacetone acrylamide; or (b) methylene-bis-acrylamide, N-vinyl pyrrolidone, and either of dimethylacrylamide or diacetone acrylamide. 
     
     
         63 . A polymer membrane having a surface coating comprising at least one hydroxymethyldiacetoneacrylamide (HMDAA) monomer of formula: 
       
         
           
           
               
               
           
         
       
       wherein R 1  and R 2  are each independently H or CH 2 OH. 
     
     
         64 . The membrane of  claim 63  wherein R 1  and R 2  are each CH 2 OH. 
     
     
         65 - 66 . (canceled)